Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2024; 20(05): 0545
DOI: 10.1055/s-0043-1763702
DOI: 10.1055/s-0043-1763702
Peptide Chemistry
Dehydrative Peptide Coupling Promoted by HBF4/MS 5Å
Ohmura S,
Ishikawa T,
Huang Q,
Horibe T,
Ishihara K.
*
Nagoya University, Japan
Dehydrative Condensation of Carboxylic Acids with Amines Promoted by HBF4/MS 5A.
Asian J. Org. Chem. 2024; e202300660
DOI: 10.1002/ajoc.202300660.
Dehydrative Condensation of Carboxylic Acids with Amines Promoted by HBF4/MS 5A.
Asian J. Org. Chem. 2024; e202300660
DOI: 10.1002/ajoc.202300660.
Key words
dehydrative condensation - tetrafluoroboric acids - molecular sieves - heterogeneous catalysis
Significance
Dehydrative coupling reactions between carboxylic acids and amines are commonly used in peptide synthesis. The authors have developed a dehydrative peptide coupling using HBF4/molecular sieve 5Å (MS 5Å).
#
Comment
This method produced various amides and dipeptides in good to high yields. In addition, MS 5Å could be recovered after the reaction, which further promoted the dehydrative condensation without HBF4.
#
#
Publication History
Article published online:
15 April 2024
© 2024. Thieme. All rights reserved
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany