Shibutani S,
Nagao K,
*,
Ohmiya H.
*
Kyoto University, Japan
A Dual Cobalt and Photoredox Catalysis for Hydrohalogenation of Alkenes.
J. Am. Chem. Soc. 2024;
146: 4375-4379
Key words
alkenes - cobalt catalysis - hydrohalogenation - photoredox catalysis
Significance
A dual photoredox- and cobalt-catalyzed protocol for the hydrohalogenation of aliphatic alkenes using inexpensive and safe-to-handle collidine salts as HX surrogates is disclosed.
Comment
This dual catalysis exploits a radical-based umpolung strategy, in which a proton and a halide anion are converted into a nucleophilic hydrogen radical and an electrophilic halogen radical, respectively.
