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Synfacts 2024; 20(05): 0479
DOI: 10.1055/s-0043-1763910
DOI: 10.1055/s-0043-1763910
Metals in Synthesis
Hydrohalogenation of Alkenes Using Collidine·HX Salts under Dual Cobalt and Photoredox Catalysis
Shibutani S,
Nagao K,
*,
Ohmiya H.
*
Kyoto University, Japan
A Dual Cobalt and Photoredox Catalysis for Hydrohalogenation of Alkenes.
J. Am. Chem. Soc. 2024;
146: 4375-4379
DOI: 10.1021/jacs.3c10133.
A Dual Cobalt and Photoredox Catalysis for Hydrohalogenation of Alkenes.
J. Am. Chem. Soc. 2024;
146: 4375-4379
DOI: 10.1021/jacs.3c10133.
Significance
A dual photoredox- and cobalt-catalyzed protocol for the hydrohalogenation of aliphatic alkenes using inexpensive and safe-to-handle collidine salts as HX surrogates is disclosed.
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Comment
This dual catalysis exploits a radical-based umpolung strategy, in which a proton and a halide anion are converted into a nucleophilic hydrogen radical and an electrophilic halogen radical, respectively.
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Publication History
Article published online:
15 April 2024
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