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Synfacts 2024; 20(05): 0483
DOI: 10.1055/s-0043-1763921
Metals in Synthesis

Cross-Electrophile Coupling Enabled by Visible-Light Palladium Catalysis

Contributor(s):
Mark Lautens
,
Colton E. Johnson
Maiti S, Ghosh P, Raja D, Ghosh S, Chatterjee S, Sankar V, Roy S, Lahiri GK, Maiti D. * Indian Institute of Technology Bombay, Mumbai, India
Light-Induced Pd Catalyst Enables C(sp 2)–C(sp 2) Cross-Electrophile Coupling Bypassing the Demand for Transmetalation.

Nat. Catal. 2024;
7: 285-294
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Key words

palladium catalysis - photocatalysis - cross-electrophile coupling - biaryl coupling

Significance

Maiti and co-workers report a highly chemoselective cross-coupling of (hetero)aryl halides under palladium visible-light catalysis. Key to success was ligand design enabling differing modes of oxidative addition between the (pseudo)halides.


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Comment

Support for the proposed hybrid aryl Pd(I)-radical species was achieved by trapping the corresponding species with N-methyl pyrrole and DMPO. The corresponding DMPO adduct was subsequently characterized by EPR.


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Publication History

Article published online:
15 April 2024

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