CDMT-Mediated Peptide Synthesis

Key words

2-chloro-4,6-dimethoxy-1,3,5-triazine - coupling reagents - peptide synthesis

Significance

The development of efficient, racemization-free methods for peptide synthesis is highly demanded in the peptide industry. In 1987, Kamiński invented 2-chloro-4,6-dimethoxy-1,3,5-triazine as an efficient coupling reagent for peptide synthesis.

Comment

A series of di-, tri-, and pentapeptides were synthesized by coupling for N-protected amino acids or corresponding peptides with amino acid ester or peptides. This protocol uses mild conditions and proceeds without concomitant racemization.

Publication History

Article published online:
13 March 2024