DOI: 10.1055/s-00000131

Synfacts

Issue 04 · Volume 20 · April 2024 DOI: 10.1055/s-014-59268

Synform

A053
Zanda, Matteo: SYNFORM ISSUE 2024/04

Synthesis of Natural Products

z0335
All PDFs of this category
0335
Total Synthesis of (±)-Daphenylline
0336
Enantioselective Total Synthesis of (–)-Daphenylline
0337
Synthesis of (+)-Archangiumide
0338
Total Synthesis of (+)-Bipolarolide A
0339
Total Synthesis of (+)-Heilonine
0340
Total Synthesis of (+)-Pedrolide
0341
Total Synthesis of (+)-Zaragozic Acid C

Synthesis of Heterocycles

z0343
All PDFs of this category
0343
Efficient Syntheses of Complex Benzoxaboracycles
0344
Late-Stage Selective Functionalization for Bioactive Indole Derivatives
0345
1,3-Dipolar Cycloaddition Approach to Functionalized Tetrahydropyridines
0346
Palladium-Mediated Synthesis of Functionalized Unsaturated Dicarbonyl Compounds
0347
Chemodivergent Cyclization of Propargylamines to Enable Indole and Quinoline Heterocycles
0348
Synthesis of Amides Using Triazine Esters as Stable Acylation Reagents
0349
Selective Synthesis of exo- and endo-3-Azabicyclo[3.1.0]hexane-6-carboxylates
0350
Synthesis of Fused Imidazoles via Iron-Catalyzed C(sp3)–H Amination–Cyclization
0351
Skeletal Editing of Indazoles via Silver-Catalyzed Carbene Insertion
0352
Copper-Catalyzed Synthesis of 4,5,6-Trisubstituted Pyrimidines
0353
Diastereoselective Scandium-Catalyzed Route to Difluorinated Pyrrolidines

Synthesis of Materials and Unnatural Products

z0355
All PDFs of this category
0355
N-Heterocyclic Olefins with Applications to ROP
0356
Sequential Annulation of Arene Diamines
0357
A Facile Access to Phosphet-2-ones
0358
Photochemical Conversion of Nitroarenes to Bicyclic Pyrrolines
0359
Rippled Nanographene Rich in Nonhexagons
0360
N-doped Holey Nanographene
0361
Azaboraacenium with Photo- and Air-Stability
0362
Antiaromatic Chalcogenopyrano Chalcogenopyrans
0363
A Rotaxane of [6]Cycloparaphenylene
0364
A One-Pot Cascade Synthesis of Phenanthrenes
0365
One-Pot Synthesis of 1,4-Azaborines from Diarylamide

Metals in Synthesis

z0367
All PDFs of this category
0367
Palladium-Catalyzed Carbonylative Cycloaddition of Acylsilanes and Imines to Access β-Lactams
0368
Synthesis of 2-Aminopyridines from 1,2,3,4-Tetrazoles via Iron/Blue Light-Promoted Benzylic C–H Activation
0369
Terminal C–H Borylation Enabled by Visible Light Iron Photocatalysis
0370
Synthesis of Branched Sulfides via Cobalt-Catalyzed Markovnikov Thiyl Radical Addition to Alkenes
0371
Asymmetric Hydrocyanation of Aromatic Alkenes by Merging Photoredox and Copper Catalysis
0372
Synthesis of Diverse 1,5-Boroacylated Products via Cooperative Cu/Pd-Catalysis
0373
Nickel-Catalyzed Intramolecular Carboamination: Efficient Synthesis of N-Heterocycles
0374
Rhodium-Catalyzed Asymmetric Aziridination of Unactivated Terminal Olefins
0375
Direct Carboxylation of Secondary Alkyl Bromides under Dual Photoredox and Nickel Catalysis
0376
Synthesis of Arylamines via a C–N Coupling, Ring Expansion and Dehydrogenative Aromatization Cascade
0377
A Copper-Catalyzed [2,3]-Stevens Rearrangement to Access Functionalized Tetrahydro Oxepines
0378
Enantioselective Synthesis of Isoindolinones via Cobalt-Catalyzed C–H Carbonylation
0379
Pd/Visible Light-Promoted 2,5-Difunctionalization/Spirocyclization of Alkene-Tethered Furans
0380
Three-Component Defluorinative Alkylboration of Alkenes Under Dual Photoredox and Copper Catalysis
0381
Doubly Enantioconvergent Construction of Vicinal Stereocenters by Iridium-Catalyzed Allylic Alkylation
0382
Strained-Alkene-Mediated Divergent Synthesis of Fluorenones and Fused Dibenzocycloheptenones
0383
Synthesis of Seven-Membered Lactones via Palladium-Catalyzed Ring-Opening [5+2] Annulation
0384
Synthesis of Ynones and γ-Butenolides with In Situ-Formed CO from a Palladium Difluorocarbene Complex
0385
Palladium-Catalyzed Asymmetric α-Arylation of Azlactones and 5H-Oxazol-4-ones
0386
Copper-Catalyzed Synthesis of Enantioenriched β-Boryl-α-Aryl Carboxylic Acids
0387
Ring Expansion of Indenes Using α-Iodonium Diazo Compounds as Functionalized Carbyne Precursors
0388
Carboxylic Phosphoric Anhydrides: New Partners for Pd-Catalyzed Decarbonylative Sonogashira
0389
Asymmetric Synthesis of γ-Alkoxy-α,β-Imides via Gold Catalysis
0390
Aerobic Asymmetric Oxidative Allylation of β-Keto Esters Enabled by Amine–Pd Catalysis
0391
The Takai–Oshima–Lombardo Methylenation of Carbonyl Compounds
0392
Stereodivergent Homocoupling of Benzoxazolyl Acetates by Dual Nickel and Copper Electrocatalysis

Polymer-Supported Synthesis

z0393
All PDFs of this category
0393
Asymmetric Hydrogenation of Acrylates by COF with Chiral Frustrated Lewis Pairs
0394
Photocatalytic Synthesis of (2-Tosylvinyl) Sulfides and Selenides by Graphitic Carbon Nitride
0395
“Activated Borane” – Porous Borane-Organic Clusters as Lewis Acid Catalysts
0396
Semihydrogenation of Alkynes with a Pd-Carbide Composite Encapsulated in an MFI Zeolite
0397
The Suzuki–Miyaura Coupling Catalyzed by Palladium on a Phenanthroline-Based COP
0398
Photocatalytic Oxidation of Benzylic C(sp3)–H Bonds, Thioanisoles, and Benzylamines
0399
Photocatalytic Hydrogenolysis of Lignin β-O-4 Models by a Ni-Containing Polyoxometalate/CdS QDs System
0400
Hydrogenation of Furfurals by Pd-Based Bimetallic Alloys in Aqueous Micelles
0401
Knoevenagel Reaction and Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Using Urea-Rich POP
0402
Light-Driven Hydrogenation of Nitroarenes by Iron Catalysts Supported on TiO2
0403
Reductive N-Formylation of Amines with CO2 Using an NHC-Based Porous Organic Polymer
0404
Decarbonylation of Thioesters Catalyzed by CeO2- or Hydroxyapatite-Supported Ni, Pd, or Rh Nanoparticles

Organo- and Biocatalysis

z0405
All PDFs of this category
0405
Organo- and Biocatalysis in One-Pot Chemoenzymatic Oxidation and Michael Reaction Cascade
0406
Stereo- and Regioselective Hydroxylation of Cyclo­butyl- and Bicyclo[1.1.1]pentylamines via Biocatalysis
0407
Catalytic Enantioselective Wagner–Meerwein Rearrangement of Alkenyl Cycloalkanes
0408
Trialkylphosphines-Catalyzed C–F Activation of Highly Fluorinated Arenes and Heteroarenes
0409
Dearomative [2π+2σ] Photocycloaddition of Phenols and Bicyclobutanes
0410
NaCl-Mediated Catalytic Enantioselective α-Chlorination of Ketones
0411
Atroposelective Synthesis of Axially Chiral 1,3-Dienes via C(sp2)–H Functionalization
0412
Photocatalyst-Free Catalytic Single-Electron Reduction by 1H-1,2,3-Triazol-5-ylidenes
0413
Radical (Hydro)Sulfonylation of Alkenes Promoted by Formation of an Electron Donor–Acceptor Complex

Innovative Drug Discovery and Development

z0415
All PDFs of this category
0415
Arenophile Cycloaddition-Mediated Dearomative Pyridine Oxidation
0416
Photoactivated Gene Therapy: Targeted Retinal Pathologies with Caged Ethinylestradiol
0417
A Twist-to-Open Mechanism for the VGIC Subtype KCNQ2 is Revealed Using a Novel Small Molecule Activator
0418
Simple Synthesis of Indazoles
0419
Novel [2+2+1] Reaction with Triplet Nitrene
0420
Straightforward Access to Azepanes from Nitroarenes
0421
Discovery of Indazole-Based Selective IRAK4 Inhibitors
0422
Selectfluor Electrochemistry Enables Site-Selective Synthesis of Versatile Aryl DABCOnium Salts
0423
Decagram-Scale Synthesis of an Anti-Cancer Drug Candidate
0424
Convenient Access to N-Difluoromethyl Amides, Urea, Carbamate and Thiocarbamate Derivatives
0425
The First Total Synthesis of Camphor and the Industrial Standard
0426
Late-Stage TBADT-Catalyzed Oxidation Guides Structural Modification to Improve Half-Life

Peptide Chemistry

z0427
All PDFs of this category
0427
Quinoline-8-carboxamides Synthesis via Aldehyde C–H Bond Activation Using Palladium Catalyst
0428
Organocatalytic Stereoselective Synthesis of β-Hydroxy-α-Amino Acids
0429
Recyclable Bicyclic Benziodazolone-Mediated Peptide Coupling Reaction
0430
B(C6F5)3-Catalyzed Diastereoselective Synthesis of Carbocyclic β-Amino Acid (CBAA) Derivatives
0431
Mn-Catalyzed Visible-Light-Mediated Synthesis of Amide via Aminocarbonylation
0432
Lewis Base-Catalyzed β-Amino Acids Synthesis from Trifluoro and Trichloro Acetamide and MBH Carbonates
0433
Synthesis of Peptides via Nicotinate-Directed Transamidations by Zinc Catalysis
0434
Synthesis of Chiral α-Vinylic Amino Acids via Enantioselective Aza-Nozaki–Hiyama–Kishi Reaction
0435
α-Functionalization of Glycine to Access Functionalized Amino Acids and Peptides
0436
Synthesis of Cross-Linked Pseudopeptides Using Pd-Catalyzed Carbonylative Coupling
0437
Synthesis of Difluoroalanine (dfa) and Their Applications in Peptide Synthesis
0438
Ru/Cu-Catalyzed Modification of Diphenyl Ketoimine Amino Acids and Peptides
0439
Two Step Synthesis of β2,2-Amino Acids from Alkylidenemalononitriles and Cbz-Gly
0440
Palladium-Catalyzed C(sp2)–H Activation for Site-Selective Functionalization of Peptides
0441
CDMT-Mediated Peptide Synthesis

Flow Chemistry

z0443
All PDFs of this category
0443
Asymmetric Rh-Catalyzed Reductive Enyne Cyclization Using a Continuous-Flow Setup
0444
Development and Exploitation of a New Flow Reactor for Electrophotocatalysis (EPC)
0445
Flow Chemistry Enables Safe, Kilogram-Scale Synthesis of 2-Hydroxypyridine-N-Oxide (HOPO)