Li P,
Xu JC.
*
Shanghai Institute of Organic Chemistry, P. R. of China
2-Bromo-1-ethyl Pyridinium Tetrafluoroborate (BEP): A Powerful Coupling Reagent for
N-Methylated Peptide Synthesis.
Chem. Lett. 2000;
29: 204-205
DOI:
10.1246/cl.2000.204
Key words
N-methyl peptides - coupling reagents - 2-bromo-1-ethyl pyridinium tetrafluoroborate (BEP)
Significance
Development of new coupling reagents for the synthesis of peptides having N-methyl amino acids is highly demanded in the peptide industry. In 1999, Xu and Li utilized 2-bromo-1-ethyl pyridinium tetrafluoroborate (BEP) as an efficient coupling reagent for the synthesis of peptides containing N-methyl amino acids.
Comment
A series of N-methyl peptides were synthesized in good yields with the help of 2-bromo-1-ethyl pyridinium tetrafluoroborate (BEP). The reaction protocol is simple and proceeds without loss of optical purity. This protocol is helpful for the synthesis of polypeptides having N-methyl amino acids.
