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Synfacts 2024; 20(07): 0779
DOI: 10.1055/s-0043-1774884
DOI: 10.1055/s-0043-1774884
Peptide Chemistry
Efficient Method for the Synthesis of N-Methylated Peptides
Li P,
Xu JC.
*
Shanghai Institute of Organic Chemistry, P. R. of China
2-Bromo-1-ethyl Pyridinium Tetrafluoroborate (BEP): A Powerful Coupling Reagent for N-Methylated Peptide Synthesis.
Chem. Lett. 2000;
29: 204-205
DOI: 10.1246/cl.2000.204.
2-Bromo-1-ethyl Pyridinium Tetrafluoroborate (BEP): A Powerful Coupling Reagent for N-Methylated Peptide Synthesis.
Chem. Lett. 2000;
29: 204-205
DOI: 10.1246/cl.2000.204.
Key words
N-methyl peptides - coupling reagents - 2-bromo-1-ethyl pyridinium tetrafluoroborate (BEP)Significance
Development of new coupling reagents for the synthesis of peptides having N-methyl amino acids is highly demanded in the peptide industry. In 1999, Xu and Li utilized 2-bromo-1-ethyl pyridinium tetrafluoroborate (BEP) as an efficient coupling reagent for the synthesis of peptides containing N-methyl amino acids.
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Comment
A series of N-methyl peptides were synthesized in good yields with the help of 2-bromo-1-ethyl pyridinium tetrafluoroborate (BEP). The reaction protocol is simple and proceeds without loss of optical purity. This protocol is helpful for the synthesis of polypeptides having N-methyl amino acids.
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Publication History
Article published online:
14 June 2024
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