Wang X,
Jin K.
*
Shandong University, Jinan, P. R. of China
Robust Chemical Synthesis of “Difficult Peptides” via 2-Hydroxyphenol-pseudoproline (ψ
2-hydroxyphenolpro) Modifications.
J. Org. Chem. 2024;
89: 3143-3149
DOI:
10.1021/acs.joc.3c02576
Key words
2-hydroxyphenol-pseudoproline - proline surrogates - difficult peptides
Significance
The synthesis of complex peptides with sequences that readily aggregate remains a huge challenge even with conventional methods. Herein, the authors report an efficient strategy to access them.
Comment
A variety of novel 2-(oxazolidine-2-yl)phenol compounds were produced as proline surrogates and utilized in accessing ‘difficult’ peptides such as thymosin α1.
