Ding Y,
Pedersen SS,
Wang H,
Xiang B,
Wang Y,
Yang Z,
Gao Y,
Morosan E,
Jones MR,
Xiao H,
Ball ZT.
*
Rice University, Houston, USA
Selective Macrocyclization of Unprotected Peptides with an ex situ Gaseous Linchpin Reagent.
Angew. Chem. Int. Ed. 2024; e202405344
DOI:
10.1002/anie.202405344
Key words
copper catalysis - cyclization - linchpin reagent
Significance
Cyclic peptides have received increasing attention due to their improved stability and cell permeability, compared to linear peptides. The authors have established a cyclization at the side chain via carbonylation using in situ generated CO.
Comment
The cyclization proceeded at the side chain of Lys-Lys, Lys-Tyr, and Lys-Phe(4-NH2) regardless of the position of the complex peptide chain in good yields by the help of Cu catalysis.
