DOI: 10.1055/s-00000131

Synfacts

Issue 08 · Volume 20 · August 2024 DOI: 10.1055/s-014-59965

Synform

A118
Zanda, Matteo: SYNFORM ISSUE 2024/08

Synthesis of Natural Products

z0783
All PDFs of this category
0783
Total Synthesis of (–)-Bipolarolide D
0784
Total Synthesis of (–)-Scabrolide A
0785
Total Synthesis of (–)-Octalactins A and B
0786
Total Synthesis of (+)-Strigol
0787
Synthesis of (+)-Verrubenzospirolactone
0788
Total Synthesis of Brassicicene A, I and K
0789
Total Synthesis of Ecteinascidin 743

Synthesis of Heterocycles

z0791
All PDFs of this category
0791
Cobalt-Mediated Hydroaminocarbonylation of Olefins under Mild Conditions
0792
Divergent Synthesis of Isoxazolo[5,4-b]pyridines
0793
Modular Approach to 2,3,5-Trisubstituted Pyridines
0794
Minisci-Type Alkylation of Heterocycles with Organoboron Derivatives Assisted by Catechol
0795
Synthesis of Fused Indoles from Formaldehyde and Amino Hydrochlorides
0796
Palladium-Catalyzed Arylation of Hydantoins with Aryl Chlorides under Mild Conditions
0797
Synthesis of N-Alkylbenzimidazoles via Organoiodine-Catalyzed Oxidative Intramolecular C–H Amination
0798
Access to Crinine-Type Amaryllidaceae Alkaloids via an Asymmetric Staudinger/aza-Wittig Reaction Approach
0799
One-Pot Photoredox Synthesis of Tetrahydroquinolines Using 3-Chloropropylbis(catecholato)silicate
0800
Cinchona Alkaloid Mediated Asymmetric Michael Addition of 3-Fluorooxindoles
0801
Scalable Synthesis of 1-Aminoethyl Oxindoles from Benzaldehydes
0802
Efficient SNAr Approach under Mild Conditions for 2-Substituted Pyrimidines

Synthesis of Materials and Unnatural Products

z0803
All PDFs of this category
0803
Stable Hexaarylethane
0804
Regioselective Polyhalogenation of Biaryls via Hypervalent Halide
0805
Enantioselective Synthesis of Molecular Nanographene
0806
Metathesis Facilitated BN-bridged Bicyclic Scaffolds
0807
Laddered Aromatic Lactams in a Loop
0808
Biocompatible Bright Near-Infrared Fluorogenic Dye
0809
Bulk Depolymerizable PMMA
0810
Tris-Azo Cycloparaphenylenes with Isomerism
0811
Modular Strategy of Cage[n]arenes
0812
Tetrapyridyl Phosphinines with Reversible Water- Activation Capability
0813
Thermally Stable, Mechano-sensitive SO2-Releasing Polymer
0814
Boronated Phenyldiethynylethylenes

Metals in Synthesis

z0815
All PDFs of this category
0815
Photochemical Gold Catalyzed Domino Reaction for the Synthesis of Indolines and Tetrahydroquinolines
0816
Asymmetric Synthesis of Fluorenols by Palladium/Chiral Norbornene Cooperative Catalysis
0817
Photoinduced Palladium-Catalyzed 1,4-syn-Difunction­alization of Cyclic 1,3-Dienes
0818
Synthesis 3-Aminoisoquinolines via a C–H Activation, Annulation Sequence Catalyzed by Cobalt
0819
Synthesis of 1,4-Dihydropyridines via Iron-Catalyzed Annulation
0820
The Ligand is in Control: Pd-Catalyzed (5+3) or [2σ+2σ] Cycloadditions of Bicyclobutanes and Vinyl Oxiranes
0821
Synthesis of Aryl-α,α-difluoroacetonitriles by Copper-Mediated Cross-Coupling of Aryl Halides with TMSCF2CN
0822
Dehydrogenation/Lactonization of of C(sp3)–H Bonds via Copper Catalysis
0823
Iridium-Catalyzed Asymmetric and Stereoinvertive Allylic Substitution with Chiral Boronic Esters
0824
BCBs as Precursors to Highly Strained Bridged Heterocycles via a Rhodium(I)-Catalyzed Reaction
0825
Hydrogen-Free Electrochemical Hydrogenation of Unactivated Alkenes under Nickel Catalysis
0826
Stereoselective Synthesis of Fused Bicyclic Systems via a Palladium-Catalyzed Domino Reaction
0827
New Electrophilic Nitrene Precursors in Rhodium-Catalyzed Skeletal Editing
0828
Dual Nickel/Titanium-Catalyzed Decyanative Silylation and Germylation of Quaternary Malononitriles
0829
Divergent Synthesis of Dihydrofurans and Tetrahydrofurans Enabled by Palladium Catalysis
0830
Enantioselective Synthesis of Tertiary Alcohols by a Nickel-Catalyzed Reductive Arylation of Ketones
0831
Nickel-Catalyzed Asymmetric Dicarbofunctionalization of Alkenes via Photochemical C(sp3)–H Bond Activation
0832
A Highly Atom-Economic Stereodivergent Synthesis of Remote 1,6-Aminoalcohols
0833
Copper-Catalyzed Synthesis of Alkylated N-Cyanamides from Dioxazolones via a Nitrogen Umpolung Strategy
0834
Palladium-Catalyzed Hydroaminocarbonylation of Alkenes Involving Inward Chain Walking
0835
Asymmetric Hydroacetalization of Vinyl Arenes under Copper Hydride Catalysis
0836
Synthesis of Allylic N,O-Acetals From Cycloalkyl Amides Under Cobalt/Photoredox Catalysis
0837
Copper-Catalyzed Synthesis of Enantioenriched Cyclopropanes
0838
C(sp2)–Heteroatom Coupling of Arylthianthrenium Salts under Nickel Photoredox Catalysis
0839
Bimodal Ring-Opening Isomerization of Vinyl Cyclopropanes via Cobalt Catalysis
0840
Nickel-Catalyzed Carboamination/Aminoborylation of Biphenylene

Polymer-Supported Synthesis

z0841
All PDFs of this category
0841
Continuous-Flow N-Alkylation of Amines Using a Heterogeneous Polysilane-Palladium Catalyst
0842
An Atomic Cobalt Catalyst for the Oxidative Cyclocondensation of Benzoheterocycles
0843
Hydrogenolysis of C–O Bonds in Alcohols, Carbonyls, and Ethers Using Pt NPs Supported on Al(PO3)3
0844
Hydrodehalogenation of Aryl Halides with a Cobalt Catalyst on N,P-Doped Porous Carbon
0845
Hydrofunctionalization of Alkenes Promoted by Site-Isolated Rh(II) Radicals in MOFs
0846
N-Allylation of Amines Using Allyl Alcohols by a Silica-Supported Pd/Cu Catalyst
0847
Photo-Induced Phosphorylation of Thiazoles and Quinoxalines Catalyzed by a Polyoxomolybdate
0848
Photoinduced Ring Expansion for the Construction of Medium-Sized Lactams via Nitrogen Radicals
0849
3D-Printed Stent-Shaped Polymeric Eosin Y-Based Photocatalysts
0850
Silica-Supported Chiral Phosphoric Acids Catalyzed C–H, C–C, and Sequential C–C/C–H Bond Formation in Flow
0851
Synthesis of α-Hydroxy-γ-Lactams Using a Single-Atom Cobalt Catalyst Supported on NC-TiO2
0852
Aerobic Oxidative C–N Coupling Catalyzed by a Binuclear Cu Cluster Bound to MOF with a Flexible Linker

Organo- and Biocatalysis

z0853
All PDFs of this category
0853
Biocatalytic Aminolysis of Esters in Water – Scalable and Sustainable Synthesis of Heteroaromatic Amides
0854
Engaging Furans in Photocycloaddition to Access Molecular Cages
0855
Organocatalytic Asymmetric Synthesis of Chiral Sulfinamides and Sulfinate Esters
0856
Intermolecular [2π+2σ] Cycloaddition of Bicyclo[1.1.0]butane with Non-Activated Alkenes
0857
Lysine as a ‘Smart’ Amine Donor for Transaminase-Catalyzed Synthesis of β-Branched Amino Acids
0858
Lewis Base-Catalyzed Chemo- and Regioselective Electrophilic Selenylation of Phenols
0859
Engineered Nitrene Transferase Enables Primary Amination of Tertiary C–H Bonds
0860
C2-Symmetric Chiral Thiol-Catalyzed Hydrogen Atom Transfer for Asymmetric Hydroamination
0861
A Novel Photoenzymatic Platform for the Synthesis of Chiral Amines via Hydroalkylation of Enamides
0862
Practical Synthesis of Chiral α-Aminophosphonates with Weak Bonding Organocatalysis at ppm Loading

Innovative Drug Discovery and Development

z0864
All PDFs of this category
0863
Discovery and Development of CNS-Penetrant IRAK4 Inhibitors
0864
Mild Lactam Synthesis from Cyclic Secondary Amines
0865
Fishing for Furans with a Diels–Alder Covalent Probe
0866
Enantioselective Nickel-Catalyzed Reductive Coupling of Alkenes with Imines for Chiral Amine Synthesis
0867
Cobalt Catalysis Enables Cross-Electrophile Coupling of Two Unusual Partners
0868
Novel Amination Reagent for Preparing 2° Amines
0869
Boron Catalysis in a Designer Enzyme
0870
Synthesis and Biological Evaluation of a Novel, Time-Dependent and Selective hOAT Inhibitor
0871
Borylative Enyne Cyclization Brings New Twist to the Synthesis of Anti-Hepatitis Drug Entecavir
0872
4-Chloropyrazolopyridine as a Tunable, Covalently Acting SNAr Electrophile
0873
Selective N-Methyl Pyrazole Synthesis Enabled by Utopia Point Bayesian Optimization
0874
C(sp3)-N Bond Formation via Deoxygenative Amination of Alcohols
0875
A Seven-Step Total Synthesis of the Non-Natural α-Amino Acid (–)-Caramboxin
0876
MgCl2 and Wet Milling Efficiently Removes Triphenylphosphine Oxide
0877
Kilogram-Scale Stereocontrolled-Synthesis of TRPA1 Inhibitor GDC-6599
0878
Exploration of a New Antithrombotic Drug – Piericone D

Peptide Chemistry

z0879
All PDFs of this category
0879
Peptide Cyclization at Side Chain of Lys-Lys, Lys-Tyr, and Lys-Phe(4-NH2)
0880
Late-Stage Michael Addition to Form Phosphorus-Containing Peptides
0881
Visible-Light-Mediated Synthesis of Unnatural Amino Acid and Peptide Derivatives
0882
Amino Acid Synthesis via Photobiocatalytic Asymmetric C(sp3)–C(sp3) Oxidative Cross-Coupling
0883
Ru(II)-Catalyzed C–H Arylation of N-Aryl Triazoles and Tetrazoles with Phenylalanine-Derived Sulfonium Salts
0884
Visible-Light-Mediated Peptide Macrocyclization via Intermolecular Interception of Desulfurization
0885
Development of Deprotective Amidation Utilizing Nms-Amides
0886
Development of Amidation via Decarboxylative Cross-Coupling of Carboxylic Acids and Isocyanides
0887
Histidine-Directed β-C(sp3)–H Arylation of Alanine-Containing Peptides
0888
Triphenylphosphine- and Iodine-Mediated Rapid Peptide Synthesis
0889
Efficient Synthesis of Bicyclic Peptides via Chemoenzymatic Tandem Cyclization
0890
Utilizing Cysteamine in Peptide Ligation
0891
Practically Simple Method for the Synthesis of N-Formyl Amino Acid Esters
0892
S-Alkylation of Cysteine-Containing Peptides

Flow Chemistry

z0893
All PDFs of this category
0893
Plug Flow Synthesis of a Key Building Block for GDC-1971