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Synfacts 2024; 20(10): 1115
DOI: 10.1055/s-0043-1775071
Peptide Chemistry

Peptide Synthesis Using Unprotected Amino Acids with N-(Z-α-Aminoacyl)benzotriazoles

Contributor(s):
Hisashi Yamamoto
,
Isai Ramakrishna
Katritzky AR, *, Suzuki K, Singh SK. University of Florida, Gainesville, USA
Highly Diastereoselective Peptide Chain Extensions of Unprotected Amino Acids with N-(Z-α-Aminoacyl)benzotriazoles.

Synthesis 2004; 2645-2652
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Key words

N-(Z-α-aminoacyl)benzotriazoles - unprotected amino acids - peptide synthesis

Significance

Development of practically handy and cost-effective methods for peptide synthesis is a highly demanding area of organic synthesis. In this study, the authors developed an elegant method for the synthesis of peptides by using unprotected amino acids with N-(Z-α-aminoacyl)benzotriazoles.


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Comment

A series of peptides were prepared by coupling between unprotected amino acids with N-(Z-α-aminoacyl)benzotriazoles. This method is practically simple and the reaction proceeded with minimum epimerization under mild reaction conditions.


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Publication History

Article published online:
13 September 2024

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