RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2024; 20(10): 1105
DOI: 10.1055/s-0043-1775072
DOI: 10.1055/s-0043-1775072
Peptide Chemistry
Rhodium-Catalyzed Macrocyclization of Peptides
Lamartina CW,
Chartier CA,
Hirano JM,
Shah NH,
*,
Rovis T.
*
Columbia University, New York, USA
Crafting Unnatural Peptide Macrocycles via Rh(III)-Catalyzed Carboamidation.
J. Am. Chem. Soc. 2024;
146: 20868-20877
DOI: 10.1021/jacs.4c05248
Crafting Unnatural Peptide Macrocycles via Rh(III)-Catalyzed Carboamidation.
J. Am. Chem. Soc. 2024;
146: 20868-20877
DOI: 10.1021/jacs.4c05248
Significance
Macrocyclic peptides gained tremendous attention in peptide drug discovery. In this study, the authors developed the Rh(III)-catalyzed macrocyclization of suitably substituted acryloyl-peptide-dioxazolone precursors with arylboronic acids to form macrocyclic peptides.
#
Comment
A series of macrocyclic peptides were synthesized by Rh-catalyzed carboamidation ligation strategy of suitably substituted acryloyl-peptide-dioxazolone precursors with arylboronic acids. This protocol is useful for the synthesis of macrocyclic peptides having unnatural amino acids.
#
#
Publikationsverlauf
Artikel online veröffentlicht:
13. September 2024
© 2024. Thieme. All rights reserved
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany