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Synfacts 2005(1): 0177-0177  
DOI: 10.1055/s-2005-916002
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Universal Strategy for the Immobilization of Chiral Dirhodium Catalysts

Contributor(s): Yasuhiro Uozumi, Masahiro Kimura
H. M. L. Davies*, A. M. Walji
University at Buffalo, The State University of New York, USA
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Publication History

Publication Date:
21 September 2005 (online)

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Significance

ArgoPore-Wang resin-supported chiral rhodium(II) catalysts 1A-E were prepared from resin 1 having a pyridine coordination group and chiral dirhodium(II) complexes A-E by simple mixing. Asymmetric inter- and intramolecular cyclopropanation of alkenes with diazo compounds were carried out with 1A-E to give up to 95% ee of cyclopropanes (e.g., equation 2). Intramolecular C-H insertions were also promoted by 1A-E with good enantioselectivity.