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Synfacts 2006(1): 0052-0052  
DOI: 10.1055/s-2005-921673
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

(S,S,S)-REMB-Catalyzed Enantioselective Aza-Michael Reactions

Contributor(s): Mark Lautens, Andrew Martins
N. Yamagiwa, H. Qin, S. Matsunaga*, M. Shibasaki*
University of Tokyo, Japan
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Publication History

Publication Date:
16 December 2005 (online)

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Significance

The aza-Michael reaction remains as one of the premier ways to synthesize β-amino carbonyl compounds. Using a heterobimetallic catalyst, a wide variety of aromatic Michael acceptors can be converted enantioselectively into β-amines with excellent yields and enantioselectivities.