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Synfacts 2006(1): 0064-0064  
DOI: 10.1055/s-2005-921731
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Rh/Chiral Diene-Catalyzed Enantioselective 1,4-Addition to β-Silyl Enones

Contributor(s): Paul Knochel, Andrei Gavryushin
R. Shintani, K. Okamoto, T. Hayashi*
Kyoto University, Japan
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Publication History

Publication Date:
16 December 2005 (online)

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Significance

Organosilicon compounds are widely used intermediates in organic synthesis. The new preparation of chiral β-silyl ketones is therefore of significant interest. These compounds can be transformed, for instance, into chiral β-hydroxyketones or chiral allylsilanes. Besides, a new example of the application of chiral dienes as ligands for enantioselective catalysis is described.