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Synfacts 2006(2): 0182-0182  
DOI: 10.1055/s-2005-921765
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Ceria/Vinylpyridine Polymer Nanocomposite-Catalyzed Biginelli Reaction

Contributor(s): Yasuhiro Uozumi, Yasunari Maeda
G. Sabitha*, K. B. Reddy, J. S. Yadav, D. Shailaja*, K. S. Sivudu
Indian Institute of Chemical Technology, Hyderabad, India
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Publication History

Publication Date:
23 January 2006 (online)

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Significance

The ceria (cerium oxide) nanoparticles supported on poly(4-vinylpyridine-divinyl benzene copolymer) 1 were prepared via in situ polymerization using Lupersol TAEC (tert-amylperoxy-2-ethoxyhexyl carbonate) and Luperox 101 [2,5-bis(tert-butylperoxy)-2,5-dimethylhexane] as initiators and PVP (polyvinylpyrroridone) as stabilizer (eq 1). Nanocomposite 1 efficiently catalyzed the Biginelli reaction in water. For example, the reaction of benzaldehyde, ethyl acetoacetate, and urea took place in the presence of 1 to give 3,4-dihydropyrimidin-2(1H)-one in 92% yield (eq 2).