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Synfacts 2006(2): 0168-0168  
DOI: 10.1055/s-2005-924798
Bioorganic Chemistry and Organocatalysis
© Georg Thieme Verlag Stuttgart · New York

A Highly Efficient Catalyst for the Enantioselective Direct Aldol Reaction

Contributor(s): Benjamin List, Subhas Chandra Pan
S. Samanta, J. Liu, R. Dodda, C. G. Zhao*
University of Texas at San Antonio, USA
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Publication History

Publication Date:
23 January 2006 (online)

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Significance

The aldol reaction is a powerful transformation in organic chemistry. Here, the authors report the C 2-symmetric bis(prolinamide) catalyst 1 for the enantioselective direct aldol reaction. With 10 mol% of the catalyst good yields (52-80%) and enantioselectivities (82-98%) were obtained for different aromatic and aliphatic aldehydes.