Download PDF
Synfacts 2006(7): 0699-0699  
DOI: 10.1055/s-2006-941861
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Rh-Catalyzed Asymmetric Arylation and Alkenylation of Isatins

Contributor(s): Mark Lautens, Yann Béthuel
R. Shintani, M. Inoue, T. Hayashi*
Kyoto University, Japan
Further Information

Publication History

Publication Date:
22 June 2006 (online)

    Permissions and Reprints

Significance

Oxindoles and in particular 3-aryl-3-hydroxy-2-oxindoles are sub-units of many biologically relevant compounds including various drug candidates. The enantioselective addition of boronic acids to isatins using [RhCl(C2H4)2]2 and (R)-MeO-MOP as a catalyst system is reported and represents a very fast and efficient access to this class of compounds.