Synthesis of (-)-Tetrodecamycin

K. Tatsuta; Y. Suzuki; A. Furuyama; H. Ikegami

doi:10.1055/s-2006-949384

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Synfacts 2006(11): 1087-1087
DOI: 10.1055/s-2006-949384

Synthesis of Natural Products and Potential Drugs

Synthesis of (-)-Tetrodecamycin

Contributor(s): Philip Kocienski, Thomas Snaddon
K. Tatsuta*, Y. Suzuki, A. Furuyama, H. Ikegami
Waseda University, Tokyo, Japan

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Publication History

Publication Date:
24 October 2006 (online)

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Significance

(-)-Tetrodecamycin is a complex tetronic acid antimicrobial agent that displays activity against Pateurella piscicida, the bacteria responsible for pseudotuberculosis in fish. Noteworthy in this synthesis is the preparation of cis-diol D by a pinacol cyclization.