Download PDF
Synfacts 2006(11): 1086-1086  
DOI: 10.1055/s-2006-949389
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Neodysiherbaine

Contributor(s): Philip Kocienski, Thomas Snaddon
K. Takahashi, T. Matsumura, G. R. M. Corbin, J. Ishihara, S. Hatakeyama*
Nagasaki University, Japan
Further Information

Publication History

Publication Date:
24 October 2006 (online)

    Permissions and Reprints

Significance

(-)-Neodysiherbaine is an agonist of AMPA-KA-type glutamate receptors and displays anticonvulsant activity. Key to this synthesis is the Negishi coupling of vinyl iodide D and functionalized organozinc reagent E using Pd(0) cata­lysis.