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Synfacts 2006(11): 1129-1129
DOI: 10.1055/s-2006-949452
DOI: 10.1055/s-2006-949452
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Enantioselective Dialkylzinc Addition to Aldehydes
M. Hatano, T. Miyamoto, K. Ishihara*
Nagoya University, Japan
Further Information
Publication History
Publication Date:
24 October 2006 (online)
Significance
Enantioselective dialkylzinc additions to aldehydes to generate chiral secondary alcohols are synthetically and pharmaceutically important intermediates. The authors describe the first example of conjugate acid-base catalysis which is argued to enhance catalytic activity.