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Synfacts 2007(1): 0095-0095
DOI: 10.1055/s-2006-955661
DOI: 10.1055/s-2006-955661
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart · New York
Enzymatic Kinetic Resolution of β-Hydroxy Ketones
A. Kirschner, U. T. Bornscheuer*
Ernst-Moritz-Arndt-Universität Greifswald, Germany
Further Information
Publication History
Publication Date:
15 December 2006 (online)

Significance
An enzymatic kinetic resolution of β-hydroxy ketones using whole-cell catalysts has been described. Baeyer-Villiger monooxygenase (BVMO) from Pseudomonas fluorescens mediates the oxidation of racemic 4-hydroxy-2-ketones (R,S)-1 to give both enantioenriched acetates (S)-2 and ketones (R)-1 in high conversions, enantioselectivities and E values. The transformation is limited to linear alkyl precursors.