Domino Hydroformylation/Organocatalytic Aldol Reaction

doi:10.1055/s-2007-991249

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Synfacts 2007(11): 1180-1180
DOI: 10.1055/s-2007-991249

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Domino Hydroformylation/Organocatalytic Aldol Reaction

Contributor(s): Mark Lautens, Praew Thansandote
O. Abillard, B. Breit*
Albert-Ludwigs-Universität Freiburg, Germany

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Publication History

Publication Date:
23 October 2007 (online)

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Significance

The first domino hydroformylation-enantioselective organocatalytic cross-aldol sequence is described between simple alkenes and aldehydes. The corresponding products are useful polypropionate building blocks and can be obtained in excellent diastereoselectivities and enantioselectivities.