Download PDF
Synfacts 2007(11): 1170-1170  
DOI: 10.1055/s-2007-991255
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Synthesis of 1,1-Disubstituted Propynes

Contributor(s): Mark Lautens, Michael Langer
H. Matsuzawa, Y. Miyake, Y. Nishibayashi*
The University of Tokyo, Japan
Further Information

Publication History

Publication Date:
23 October 2007 (online)

    Permissions and Reprints

Significance

The authors recently reported on the ruthenium-catalyzed enantioselective propargylic substitution reaction with acetone (Angew. Chem. Int. Ed. 2005, 44, 7715). Herein they extend the methodology to an asymmetric Friedel-Crafts-type alkylation which affords 1,1-disubstituted unprotected propynes in moderate to good yield and good enantioselectivity.