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Synfacts 2007(11): 1166-1166  
DOI: 10.1055/s-2007-991272
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Gold-Catalyzed Addition of Aldehydes to 1,6-Enynes

Contributor(s): Hisashi Yamamoto, Marina Naodovic
M. Schelwies, A. L. Dempwolff, F. Rominger, G. Helmchen*
Universität Heidelberg, Germany
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

The methodology presented here is the first example of intramolecular addition of carbonyl compounds to 1,6-enynes in the presence of cata­lytic amounts of gold(I). A remarkable feature of this reaction is the formation of a novel type of tricyclic compounds with two quaternary centers in vicinal positions.