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Synfacts 2008(5): 0484-0484  
DOI: 10.1055/s-2008-1072660
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Strontium-Catalyzed Enantioselective Michael Reactions

Contributor(s): Mark Lautens, Praew Thansandote
M. Agostinho, S. Kobayashi*
The University of Tokyo, Japan
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Publication History

Publication Date:
23 April 2008 (online)

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Significance

The authors describe the first report of an asymmetric strontium catalyst and an example of an asymmetric reaction catalyzed by a chiral strontium complex. This Michael addition of malonates to enones is catalyzed by Sr(II) and a chiral sulfonamide ligand, and occurs in good yields and excellent enantioselectivities for a broad substrate scope.