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Synfacts 2008(5): 0510-0510  
DOI: 10.1055/s-2008-1072666
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Rhodium-Catalyzed Stereoselective Synthesis of Nitrile-Substituted Cyclopropanes

Contributor(s): Mark Lautens, Valentina Aureggi
J. R. Denton, K. Cheng, H. M. L. Davies*
State University of New York, Buffalo, USA
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Publication History

Publication Date:
23 April 2008 (online)

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Significance

The development of a new rhodium catalyst for an efficient stereoselective synthesis of nitrile-substituted cyclopropanes is reported. The cyclopropane derivatives are prepared in high yields and with moderate to high diastereo- and enantioselectivities.