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Synfacts 2008(7): 0744-0744
DOI: 10.1055/s-2008-1077832
DOI: 10.1055/s-2008-1077832
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Palladium-Catalyzed Cross-Coupling Reactions with Tricyclopropylbismuth
A. Gagnon*, M. Duplessis, P. Alsabeh, F. Barabé
Boehringer Ingelheim Canada Ltd., Laval, Canada
Further Information
Publication History
Publication Date:
20 June 2008 (online)

Significance
Tricyclopropylbismuth was efficiently used in Pd-catalyzed cross-coupling reactions with various aryl- and heteroaryl iodides, bromides, chlorides and triflates. The reaction proceeds with tolerance of a broad spectrum of sensitive groups, such as keto or aldehyde functionalities without requiring strict anhydrous conditions. The transfer of an ethyl group was also realized using triethylbismuth under similar cross-couling conditions.