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Synfacts 2008(7): 0715-0715
DOI: 10.1055/s-2008-1077844
DOI: 10.1055/s-2008-1077844
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Nitroaldol Reaction Catalyzed by a Bisoxazolidine Ligand
S. Liu, C. Wolf*
Georgetown University, Washington, D.C., USA
Further Information
Publication History
Publication Date:
20 June 2008 (online)

Significance
This report describes the efficient and enantioselective synthesis of chiral β-amino alcohols derived from nitromethane and the diastereoselective synthesis derived from nitroethane. Typically expensive catalysts or silyl nitronates are required to achieve high selectivity. Avoiding these drawbacks the authors demonstrate the utility of their system towards the Henry reaction.