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Synfacts 2008(7): 0666-0666  
DOI: 10.1055/s-2008-1077857
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-Stemonamide

Contributor(s): Philip Kocienski, Stewart Eccles
T. Taniguchi, G. Tanabe, O. Muraoka, H. Ishibashi*
Kanazawa University and Kinki University, Osaka, Japan
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Publikationsdatum:
20. Juni 2008 (online)

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Significance

Stemonamide is a member of the family of stemona alkaloids, which are isolated from the roots of Stemona japonica, used for the treatment of coughs and as pesticides in traditional Chinese and Japanese medicine. This synthesis relies on a radical cascade to construct the tri­cyclic core of stemonamide.