Asymmetric Iridium-Catalyzed Hydrogenation of Vinyl Ether Esters and Alcohols

doi:10.1055/s-2008-1078463

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Synfacts 2008(7): 0733-0733
DOI: 10.1055/s-2008-1078463

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Asymmetric Iridium-Catalyzed Hydrogenation of Vinyl Ether Esters and Alcohols

Contributor(s): Mark Lautens, Praew Thansandote
Y. Zhu, K. Burgess*
Texas A&M University, College Station, USA

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Publication History

Publication Date:
20 June 2008 (online)

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Significance

The authors describe the asymmetric hydrogenation of vinyl ether esters and alcohols, which could not be effectively hydrogenated using the popular P,N-Ir catalysts. Good to excellent conversions and enantioselectivities were observed for a variety of substrates.