DOI: 10.1055/s-00000131

Synfacts

Issue 02 · Volume 16 · February 2020 DOI: 10.1055/s-010-45578

Synform

A17
Zanda, Matteo: SYNFORM ISSUE 2020/02

Synthesis of Natural Products and Potential Drugs

z0119
All PDFs of this category
0119
Synthesis of (–)-Viridin and (–)-Viridiol
0120
Synthesis of a RORγt Inverse Agonist
0121
Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Agent
0122
Total Synthesis of (–)-Penicimutanin A and Related Congeners
0123
4-(Difluoromethyl)pyridin-2-amine, a Key Intermediate for Lipid Kinase Inhibitors PQR620 and PQR530
0124
Synthesis of Parsaclisib
0125
Synthesis of a Harziane Diterpenoid
0126
Synthesis of (+)-6-epi-Ophiobolin A
0127
Synthesis of (–)-FR901483 and (+)-TAN1251C
0128
Synthesis of the Indoleamine 2,3-Dioxygenase Inhibitor Linrodostat
0129
Pyrazolocarboxamide Inhibitors of Receptor Interacting Protein 2 Kinase
0130
Synthesis of HIV-1 Entry Inhibitor BNM-III-170
0131
Synthesis of the Pyrrolidine Core of ABBV-3221
0132
Synthesis of GDC-5338
0133
Total Synthesis of (–)-Streptide
0134
Synthesis of JAK Inhibitor ASP3627
0135
A Short Synthesis of Cubane
0136
Synthesis of Monobactam 1

Synthesis of Heterocycles

z0137
All PDFs of this category
0137
Sweet Ligand: Use of Galacturonic Acid in Copper-Catalyzed N-Arylation of Heteroarenes
0138
Oxazoline Synthesis by Using the XtalFluor-E Reagent
0139
Organocatalytic Approach to Spirooxindoles
0140
Synthesis of Sulfonylpyrroloindoles via Photocatalytic Sulfonylation/Cyclization Reactions
0141
Synthesis of Fused Pyridines through a Rhodium-Catalyzed Rearrangement of Furan-Linked Triazoles
0142
Difluoromethylation of 1,2,4-Triazinones by a Copper-Catalyzed Interrupted Click Reaction
0143
Biaryls from Anilines and Aryl Sulfoxides through Sigmatropic Rearrangement
0144
Three-Component Synthesis of Thienothiazoles from Acetophenones
0145
Synthesis of Benzothiophenes by a Twofold C–H Functionalization
0146
Metal-Free Synthesis of Aza-Fused Heteroaromatics
0147
Asymmetric Synthesis of 3,6-Dihydropyridinones
0148
Three-Component Synthesis of Tetrazoles Utilizing ZSM-5 Heterogeneous Catalysis
0149
Pyridotriazole as Carbene Precursor in Rhodium-Catalyzed Synthesis of 3H-Indoles
0150
Copper-Catalyzed C–H Activation Approach to Benzofurans by Using a Traceless Directing Group

Synthesis of Materials and Unnatural Products

z0151
All PDFs of this category
0151
Cage the Coronene: A Coordination Capsule for Polyaromatics Separation
0152
From Light to Heat: Synthesis of Azo D-π-A Dyes as Photothermal Agents
0153
Twists and Turns: Enantioselective Synthesis of Bis-benzofuran Atropisomeric Oligoarenes
0154
Party of Porphyrins
0155
Regioselective C–H Activation of Naphthalene
0156
Polycyclic Quaternary Ammonium Salts Put Under the Spotlight and Fluoresces
0157
Synthesis of Dissymmetric Molecular Machines via Sequential Cross-Couplings
0158
Pillar[5]arenes are Old: Tiara[5]arenes are Gold
0159
Seeing the Light with Complex Spiro-Polymers
0160
Indole and Phenanthridine Derivatives as Simple as One-Pot, Two-Step, Three-Part
0161
Molecular Encapsulation to Suppress the Intermolecular Aggregation of Perylene Diimides
0162
Stretching Out Indacenodithiophene Polymers

Metals in Synthesis

z0163
All PDFs of this category
0163
Copper-Mediated Late-Stage Fluorination of Arenes Using Photoredox Catalysis
0164
Using Sequential Multi-Metal Catalysis for Remote Functionalization of α,β-Unsaturated Carbonyls
0165
Regioselective Synthesis of Tetrasubstituted Olefins via an Alkenyl Catellani Reaction
0166
Copper-Catalyzed Stereoselective Synthesis of Quaternary Homoallylic Alcohols Using CO2
0167
Steric Control in a Palladium-Catalyzed C–H Alkynylation of Arenes
0168
Electrochemical Iridium-Catalyzed C–H Functionalization of Vinylic C–H Bonds
0169
Benzonitrile Synthesis via a Nickel-Catalyzed Reductive Coupling
0170
Directing-Group-Free Palladium-Catalyzed C–H Functionalization–Carbonylation–Cyclization Cascade
0171
Titanium-Catalyzed Mono-Decyanation of Geminal Dinitriles
0172
Diynes through Electrochemical Gold Redox Catalysis
0173
Preparation of Chiral Difluoromethyl Cyclopropenes
0174
Cyanide-Free Hydrocyanation of Olefins
0175
Oxidative Nickel-Catalyzed Heck Arylation
0176
Palladium(0)-Catalyzed syn-1,2-Carboboration and Carbosilylation
0177
Nickel-Catalyzed Dearomative Allylation Using Allylic Alcohols
0178
Synthesis and Functionalization of cis-1,2-Aminoborylated Cyclobutanes
0179
Photoredox/Nickel Dual Catalyzed Synthesis of E- and Z-Configured 1,4-Dienes
0180
Enantioselective Ruthenium(II)-Catalyzed Coupling of Oxabenzonorbornadienes and Alkynes
0181
Zirconium-Catalyzed Hydroaminoalkylation of Primary Benzylamines
0182
Preparation of β-Aryl Aldehydes
0183
Hydroacylation of Styrenes
0184
Homo-aldol Reactions of Unsaturated Carbamates
0185
Alkoxylation of Benzylic C–H Bonds
0186
Aluminum-Catalyzed Asymmetric Formal Hydrogenation of Heteroaryl Ketones
0187
Ruthenium-Catalyzed Cleavage of Unstrained Aryl–Aryl Bonds
0188
Allenylsilanes from Propargyl Dichlorides under Copper Catalysis
0189
Palladium-Catalyzed Borylation Cyclization Cascade Reactions Generating 5- and 6-Membered Heterocycles
0190
Stereospecific Hydroxymethylation Catalyzed by Manganese
0191
Rhodium-Catalyzed Intramolecular C–H Insertion

Polymer-Supported Synthesis

z0193
All PDFs of this category
0193
Selective Hydrogenation of Nitroarenes Catalyzed by Nanostructured Tungsten Disulfide
0194
Hydrogenation of Arenes to Cyclohexanes Catalyzed by Silica-Supported Cobalt Nanoparticles
0195
Synthesis of [1,2,3]Triazolo[1,5-a]pyridines on a Mesoporous Silica Supported Copper Catalyst
0196
Benzylic C–H Oxygenations Under Photo-Irradiation Catalyzed by g-C3N4
0197
Micellar Buchwald–Hartwig Aminations Catalyzed by Cu–Pd Nanoparticles Supported on Carbon
0198
Synthesis of Quinazolines and Quinazolinones on an Iron Nanocomposite Catalyst
0199
Porous Organic Polymer-Supported Palladium Catalyst for Suzuki–Miyaura Coupling in Water
0200
Synthesis of Diarymethyl Sulfones with Amberlyst-15
0201
Oxidation of Secondary Alcohols with a PS-Supported Hypervalent Iodine Compound
0202
Synthesis of Phenoxathiin Derivatives Catalyzed by Copper Supported on OMS-2
0203
Suzuki–Miyaura Coupling in Water Catalyzed by Graphene Acid Supported Pd Nanoparticles
0204
Au@ZnO Nanoparticles for Photocatalytic Trifluoromethylation of Aromatic Compounds
0205
Heck and Suzuki–Miyaura Reactions with Palladium Supported on Microporous Organic Polymers
0206
Oxidation of Sulfides to Sulfoxides or Sulfones Using Magnetic Acidic Boehmite Nanoparticles

Organo- and Biocatalysis

z0207
All PDFs of this category
0207
Stereodivergent Chemoenzymatic Oxidative Dearomatizations in Natural Product Syntheses
0208
Triflimide-Catalyzed Peterson Olefinations
0209
Organoselenium-Catalyzed Asymmetric syn-Diamination of Alkenes
0210
Predictive Analysis to Expand the Heterocycle Scope of the Catalytic Asymmetric Minisci Reaction
0211
Asymmetric Brønsted Acid Catalyzed Oxa-Pictet–Spengler Reactions of Tryptophols with Ketals
0212
Organocatalyst–Metalloid Complexation Enables A Highly Stereoselective Reduction of Free Indoles
0213
NHC Catalysis Enables Radical Acylfluoroalkylation of Olefins and Aldehydes
0214
Asymmetric α-Alkylation of Piperidin-2-ones through Phase-Transfer Catalysis
0215
Photoexcited Flavoenzymes in an Asymmetric Redox-Neutral Radical Cyclization

Chemistry in Medicine and Biology

z0217
All PDFs of this category
0217
Caged Aptamers for Improved Cancer Imaging
0218
Sticking a Label on Tyrosine
0219
Refining Selectivity of p38 MAP Kinase Inhibitors
0220
A First-in-Class, Clinically-Relevant Covalent Inhibitor of KRAS(G12C)
0221
DNA-Compatible Conversion of Primary Amines into Azides
0222
Efficient Multigram Synthesis of Dibenzoazacyclooctyne for Strain-Promoted Alkyne–Azide Cycloadditions
0223
Dual Inhibitors of OGG1/NUDT1 for Probing Disease States
0224
Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6
0225
Biosynthetic Engineering of Polyketide Synthase Modules Towards New Enacyloxin Antibiotics
0226
The First FDA-Approved Antibody-Drug Conjugate

Peptide Chemistry

z0227
All PDFs of this category
0227
Histidine-Specific Modification of Peptides Promoted by Visible Light
0228
DMAP-Catalyzed Peptide Bond Formation by Using Phosphorus Pentoxide
0229
Stereoselective Macrocyclization of Peptides in CyClick Chemistry
0230
Palladium-Catalyzed γ-C(sp3)–H Arylation of Amino Acids and Peptides
0231
Pd-Catalyzed α-Allylation of Trifluoropyruvates to Give α-Allyl(α-trifluoromethyl)amino Acids
0232
Synthesis of α-Amino Acid Derivatives through Palladium-Catalyzed Hydrogenation
0233
Trifluoromethylation on the Side Chain of Tryptophan-Containing Oligopeptides
0234
Palladium-Catalyzed Modification of α-Amino Acid Derivatives and Peptides
0235
Chemical Synthesis of N-Sulfated Amino Acids and Peptides
0236
Peptide Cyclization by Using an α-Azido-N-Fmoc-Amino Acid
0237
Synthesis of Cα-Substituted Proline Derivatives Based on Memory of Chirality

Flow Chemistry

z0239
All PDFs of this category
0239
Synthesis of ACE Inhibitors in Flow
0240
Nickel-Catalyzed Cross-Couplings of Redox-Active Esters and Aryl Halides in Flow
0241
Hydrogenation of Cinnolines into 1,4-Dihydrocinnolines in a Continuous Flow System
0242
Photochemical Cleavage of 2-Nitrobenzyl Esters of Uronic Acids in Continuous Flow
0243
Biocatalytic Oxidation of Saccharides in Continuous Flow
0244
Wolff–Kishner Reductions Using a Silicon Carbide Flow Reactor