DOI: 10.1055/s-00000131

Synfacts

Issue 06 · Volume 16 · June 2020 DOI: 10.1055/s-010-48511

Synform

A80
Zanda, Matteo: SYNFORM ISSUE 2020/06

Synthesis of Natural Products and Potential Drugs

z0617
All PDFs of this category
0617
Asymmetric Total Synthesis of (+)-Waihoensene
0618
Total Synthesis of (±)-Ganocin A
0619
Synthesis of Monobactam Antibiotic LYS228
0620
Synthesis of Lamivudine
0621
Synthesis of PPARα Agonist GW641597X
0622
Synthesis of Taniborbactam (VNRX-5133)
0623
Total Synthesis of (+)-Cotylenin A
0624
Synthesis of (+)-Cerapicol
0625
Synthesis of (+)-Conocenolide E and (+)-10,11,12-Trihydroxytremulenone
0626
Synthesis of SUVN-911
0627
One-Pot Synthesis of a TGFβRI Inhibitor
0628
Synthesis of a Janus Kinase Inhibitor
0629
Total Synthesis of Pyrolaside B
0630
Synthesis of Islatravir
0631
Total Synthesis of (±)-Periplanone B

Synthesis of Heterocycles

z0633
All PDFs of this category
0633
Synthesis of Alkene Carbonates through Carbon Dioxide Fixation Using Perfluorinated Triol Catalysts
0634
Triazapentalene Synthesis by N–N Bond Formation
0635
Sulfinylation of Indoles, Pyrroles, and Thiophenes
0636
Ligand-Free Palladium(II)-Mediated Synthesis of 2,4-Disubstituted 1,3-Thiazoles
0637
Determination of Basicities and Nucleophilicities of a Series of Organocatalysts
0638
Direct C-2 Carboxylation of Electron-Deficient Indoles
0639
Iridium-Catalyzed Synthesis of Indoles and Indolines
0640
Synthesis of β-Lactams by a Kharasch–Sosnovsky Reaction
0641
Nickel(0)-Catalyzed Enantioselective Synthesis of Butenolides and Lactams
0642
Synthesis of Seven- and Nine-Membered Heteroatom-Containing Rings
0643
Synthesis of 1,2,4-Oxadiazoles from Alkynes and Nitriles
0644
Silver Acetate-Catalyzed Groebke-Blackburn-Bienayme Reaction to Synthesize Imidazo[1,2-a]Pyridines
0645
Synthesis of [6,5]-Spirocycles through Redox-Neutral Cyclizations of Aurones
0646
Stereoselective C–H Cyclopropanation of N-Phenoxysulfonamides
0647
Access to Functionalized Chromanes by Asymmetric [4+2]-Cycloaddition

Synthesis of Materials and Unnatural Products

z0649
All PDFs of this category
0649
Big Waggles Don’t Throw Off the Rotation
0650
Octapodal Corannulene Porphyrin Captures Fullerene
0651
A Shocking Approach to Axially Chiral Aldehydes
0652
Whew, Vinyl-y! Gold-Catalyzed Synthesis of Vinyl Ethers from Diynes and Ketones
0653
SNAr-Based Synthesis of Chalcogen-Containing Helicenes
0654
New Triarylamine Radical Shakes the Blues
0655
A Greener Way to Asymmetrical Triarylamines
0656
Lowering the LUMO: A Macrocyclic Organoborane
0657
Living Polymers via Cumulation of β-Pinene
0658
Diradicaloid Cage with 3D Global Aromaticity
0659
Convert that COF
0660
Polyynes to Polyfused Chalcogenophenes

Metals in Synthesis

z0661
All PDFs of this category
0661
Nickel-Catalyzed Cross-Electrophile Coupling using Electrochemistry
0662
Hydrogenation of Alkenes and Arenes Catalyzed by Bulky Alkaline Earth Metal Amides
0663
Manganese-Catalyzed Methylation of C(sp3)–H Bonds α to Heteroatoms
0664
Rhodium-Catalyzed Asymmetric Synthesis of Axially Chiral Polyaromatic Hydrocarbons
0665
Dual-Metal Photocatalyzed Diastereoselective Isomerization of Allyl Chlorides to Chlorocyclopropanes
0666
1,2-Diarylation of Alkenes Using Gold Catalysis
0667
Preparation of Biaryls by Organic Oxidants
0668
Decarboxylative para-Selective C–H Functionalization
0669
Chromium-Catalyzed Cyclopropanation
0670
Picolinate-Directed Arene meta-C−H Amination via FeCl3 Catalysis
0671
Oximes as Directing Groups for Iridium-Catalyzed β-Alkynylation of Primary C(sp3)–H Bonds
0672
Enantioselective Aminomethylations
0673
Enantioselective Conjunctive Cross-Couplings Leading to α-Boryl Allenes
0674
Enantioselective Radical Reactions by Cu(I)/Chiral Phosphoric Acid Cooperative Catalysis
0675
Cobalt-Catalyzed Radical Hydroxytrifluoromethylation of Alkenes
0676
C–H Functionalization of Alkanes Using Cerium Catalysis
0677
Nickel-Catalyzed Branched-Selective α-Crotylation of Ketones with 1,3-Butadiene
0678
Synthesis of 5-Aryltetrazoles
0679
Nickel-Catalyzed Decarbonylative Amination of Esters
0680
Titanium-Catalyzed Anti-Markovnikov Alcohol Synthesis via Epoxide Ring Opening Using Green Light
0681
Borocarbonylative Copper-Catalyzed Four-Component Coupling
0682
Nickel-Catalyzed Acylation of Pyridinium Salts
0683
Ni-Catalyzed Synthesis of 1,1-Diarylalkanes via Chain-Walking Hydroarylation of Alkenes with Boronic Acids
0684
Palladium-Catalyzed Enantioselective Hydroarylation of Alkenes Using a Chiral Transient Directing Group
0685
Enantioenriched Amine Derivatives by Pd- and Cu-Catalyzed Arylation and Acylation of Alkylzincs
0686
Asymmetric Hydrogenation–Reductive Amination Cascade for the Synthesis of Julolidines
0687
Electrophilic Amination of Diorganozinc Reagents Using N-Hydroxylamine Benzoates

Polymer-Supported Synthesis

z0689
All PDFs of this category
0689
An Atomically Dispersed Platinum Catalyst for the Catalytic Diboration of Alkynes
0690
Domino Knoevenagel/Hetero-Diels–Alder Reaction Catalyzed by Magnetically Separable Silica
0691
SAB-15-Supported Rose Bengal as a Heterogeneous Photoredox Catalyst
0692
C–H Halogenation of 2-Arylpyridines on Salen-Based Hypercrosslinked Polymer-Supported Palladium
0693
Catalytic Hydrogenation and Photooxidation on a Flavin-Containing Mesoporous Network Polymer
0694
Synthesis of Cyclohexylamines Catalyzed by Nickel Supported on Alumina
0695
Preparation of 3-Alkoxyquinoxalin-2-ones by Electrooxidative C–H/O–H Cross-Coupling
0696
Pd-Catalyzed Z-Selective Transfer Hydrogenation of Internal Alkynes with Butane-1,4-diol
0697
Photocatalytic Oxidation of Alcohols to Aldehydes and Ketones Catalyzed by TiO2-P25
0698
Copper(II)/Ascorbic Acid-Coated TiO2 Photocatalyst for Aerobic Oxidation of Benzylic Alcohols
0699
Synthesis of Anilines and N-Heterocyclic Aromatic Compounds Catalyzed by Ni/C Nanocomposites
0700
Hydrogenation of Nitroarenes by Formic Acid on N-Doped-Carbon-Supported Iron Nanoparticles

Organo- and Biocatalysis

z0701
All PDFs of this category
0701
Photoexcitation of an Acridine Radical Generates a Strong Organic Single-Electron Reductant
0702
Novel Borate-Ion Catalyzed Asymmetric Prins-Type Cyclization
0703
Biocatalytic Oxidation of Silanes to Silanols
0704
Chiral Phosphoric Acid Catalyst Serves a Dual Function in an Asymmetric Antilla Allylation of Aldehydes
0705
HyperBTM-Catalyzed Asymmetric Tandem Sequential Synthesis of Tetrahydroindolizines
0706
Strongly Acidic and Enzyme-Like Catalysts in Diels–Alder Reactions with Cross-Conjugated Dienophiles
0707
A Catalytic Enantioselective Allenoate–Claisen Rearrangement
0708
A Transition Metal-Free Catalytic Approach Towards Selective Transformations of ortho-Quinone Methides
0709
Supramolecular Catalysis Permits Access to the Presilphiperfolanol Framework
0710
Trapping an Achiral Anion Inside a Chiral Macrocycle for Enantioselective Catalysis
0711
An Asymmetric Tail-to-Head Cyclization of Neryl Chloride Analogues

Chemistry in Medicine and Biology

z0713
All PDFs of this category
0713
α-Ketoamide Inhibitors of SARS-CoV-2 Main Protease
0714
Azithromycin – An Antibiotic to Fight COVID-19?
0715
Crystal Structure of the Main Protease of Human Coronavirus NL63
0716
Hydroxychloroquine – An Antimalarial to Fight COVID-19?
0717
C–H Trifluoromethylation Enabled by a Combination of Decatungstate and Copper Catalysis
0718
Irreversible Covalent Inhibition of TrxR1 Prevents STAT3-Dependent Transcription Activation
0719
MicroMap: Precise Proximity Labeling of Cell Surface Proteins
0720
TREK Channel Family Activator for Relief of Pain and Neurogenic Inflammation
0721
Unleashing the Full Power of the Streptavidin–Biotin Technology in Cellular Uptake
0722
Phosphoglycolipids with Immunomodulatory Activity
0723
Photocaged Dopamine Receptor Ligands
0724
A Vincamine-Derived HCRTR2 Agonist Prevents Morphine-Seeking Behavior in Mouse Models
0725
In Vivo Optochemical Control of Glutamate Receptors with Cloaked Glutamates
0726
Accelerating Aiolos Ablation
0727
Clickable UDP-Galactose Analogues

Peptide Chemistry

z0729
All PDFs of this category
0729
Iridium-Catalyzed Synthesis of Quaternary α-Trifluoromethyl α-Amino Acids
0730
Tantalum-Catalyzed Formation of Amide Bonds
0731
Tantalum-or Titanium-Catalyzed Peptide Synthesis
0732
Organocatalytic Synthesis of Axially Chiral Biaryl Amino Acids
0733
Copper-Catalyzed Three-Component Coupling to Form α-Halo β-Amino Acid Derivatives
0734
Copper-Catalyzed Stereoselective Synthesis of α-Amino Acid Precursors
0735
Ytterbium-Catalyzed Synthesis of γ-Amino Acid Derivatives
0736
Asymmetric Mannich-Type Reaction to Access Unnatural Amino Acids
0737
Synthesis of Unnatural α-Amino Acids under Visible-Light Irradiation
0738
Modification of Peptides through C(sp3)–H Alkylation
0739
Catalyst-Free Synthesis of α-Amino Acid Derivatives
0740
Metal-Free Synthesis of α-Amino Acid Derivatives from α-Bromo Amides
0741
Chemical Ligation to Synthesize N-Hydroxy Peptides from O-Acyl Hydroxamic Acids

Flow Chemistry

z0743
All PDFs of this category
0743
Peptide Synthesis in Continuous Flow
0744
Aryl Alkyl Ether Formation via Copper-Catalyzed Photoredox Driven C–O Cross-Coupling
0745
Flow Synthesis of Anilines through Photoredox/Ni(II)-Catalyzed C–N Cross-Coupling: Tetracaine
0746
Aryl, Heteroaryl, and Benzylic Functionalization Using Potassium Organometallics Generated in Flow

Erratum

0747
Wiberg, K B; Walker, F H: V1, Rotate: [1.1.1]Propellane Prepared to Takeoff