DOI: 10.1055/s-00000131

Synfacts

Issue 03 · Volume 18 · March 2022 DOI: 10.1055/s-012-52863

Synform

A38
Zanda, Matteo: SYNFORM ISSUE 2022/03

Synthesis of Natural Products and Potential Drugs

z0227
All PDFs of this category
0227
Total Synthesis of (±)-Dalesconol A
0228
Synthesis of (+)-Quassin
0229
Synthesis of Molnupiravir
0230
Synthesis of Molnupiravir from Cytidine
0231
Synthesis of (–)-Plebeianol A
0232
Total Synthesis of Bisdehydrotuberostemonine D and Bisdehydrotuberostemonine E
0233
Total Synthesis of (–)-Calycanthine
0234
Synthesis of an Aminoquinazoline LRRK2 Inhibitor
0235
Manufacturing Route for Molnupiravir from Uridine
0236
Total Synthesis of (±)-Galanthamine and (±)-Lycoramine
0237
Synthesis of a Spiro-azaindoline Inhibitor of Hematopoietic Progenitor Kinase 1
0238
Synthesis of a Pyrazolopiperazine BACE1 Inhibitor
0239
Total Synthesis of (±)-Progesterone

Synthesis of Heterocycles

z0241
All PDFs of this category
0241
Enantioselective Synthesis of 1,4-Benzodiazepinones and 1,4-Benzoazepinones
0242
Enantioselective Synthesis of Bispiro[Oxindole-Pyrrolidine-Pyrazolone] Derivatives
0243
Skeletal Editing through Nitrogen Deletion: Synthesis of Complex Cyclobutanes from Pyrrolidines
0244
Metal-Catalyzed Synthesis of Benzomorpholines
0245
Rhodium-Catalyzed Synthesis of N-Arylaziridines
0246
Solvent-Free Synthesis of 3-Trifluoromethyl-1,2,6-Thiadiazine 1-Oxides
0247
Bronsted Acid-Catalyzed Synthesis of Spirolactams by Dearomatization of (Het)arenes
0248
Annulation Reaction To Construct 2-Aryl-5-Amino- 2H-Tetrazoles
0249
Increased 3D Character of Heterocyclic Systems through Efficient C(sp3)–C(sp3) Bond Formation
0250
Homogeneous Stable Organic Reductants for Cross-Electrophile Coupling Reactions
0251
Synthesis of Allocolchicine Analogues through Construction and Removal of P-centered Radicals
0252
One-Pot Access to Spiropyrrolidines from Azidoboronic Acids and N-Sulfonylhydrazones
0253
Transition-Metal-Free Cross-Coupling To Form 2-Pyridyl Derivatives
0254
Synthesis of Heterocycle-Fused Pyrazoles via Cascade Wolff Rearrangement/Acylation
0255
Sulfur-Mediated Benzoxazole/Benzothiazole Synthesis from Olefins and Aminophenols or Iodoanilines

Synthesis of Materials and Unnatural Products

z0257
All PDFs of this category
0257
To Infinitene and Beyond
0258
Hitching a Ride on Gem-Dimethylcyclopentanes to the Third Dimension
0259
Breaking the Symmetry in [1]Benzothieno[3,2-b][1]Benzothiophene (BTBT)
0260
Sonogashira Coupling Went Mechanochemical
0261
Reliable Host–Guest Chemistry for Alkene Assay
0262
Would You Like Some Imidazoliums in Your Polycyclic Aromatic Hydrocarbons?
0263
Rhodium-Catalyzed Tetrasubstituted Vinyl Sulfides (TVSs) Synthesis
0264
The Dithiocatechol’s Out of the Bag
0265
Facile Borylation to Expanded Heterohelicene
0266
Ring Expansion of Difluorothiiranes towards Thienothiophene and Thienofuran
0267
Let’s Get Ready to Rh-umble! Thiophene and Cyclopropane Enter the Ring
0268
Three’s Company: B-, N-, and S-Doped TADF Emitters

Metals in Synthesis

z0269
All PDFs of this category
0269
Thermodynamic Control Enables trans-Selective Isomerization of Vicinal Diols via Iridium Photocatalysis
0270
Bismuth-Catalyzed Sulfonyl Fluoride Synthesis from Boronic Acids
0271
Access to Oxazaborolidines by Catalytic Cycloaddition of 1,2-Azaborines and Vinyl Ethylene Carbonate
0272
Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Bromides with Vinyl Acetate
0273
Asymmetric Homologation Reaction of Cyclic Ketones with CF3CHN2 as Trifluoromethylation Reagent
0274
Palladium/Photoredox Catalysis: Branched-Selective Asymmetric Allylic Benzylation
0275
Nickel-Catalyzed Alkyne Difunctionalization Using Two Distinct sp3-Hybridized Electrophiles
0276
Asymmetric Propargylic Substitution Enabled by Synergistic Nickel and Chiral Anion Catalysis
0277
Pd-Catalyzed Intermolecular Asymmetric Allylic Alkylation Using β-Keto Acids as Enolate Precursors
0278
Nickel-Catalyzed Cross-Electrophile Coupling of Vinyl Acetates and Alkyl Bromides
0279
An Efficient (E)-Selective Semihydrogenation of Alkynes
0280
Atroposelective Copper-Catalyzed C–O Coupling of Resorcinol-Containing Quinazolinones
0281
Putting a Nickel into the JukeB(i)ox: A Sound Synthesis of Secondary Alcohols by Reductive Cross-Coupling
0282
Cobalt- and Nickel-Catalyzed CF2R Radical Addition and Chain-Walking of Alkenes
0283
Ketone Synthesis Enabled by a Nickel/Photoredox Cross-Electrophile Coupling of Two Distinct Esters
0284
Photoisomerization of Oximes Leading to Nonclassical Beckmann Rearrangement Products
0285
Palladium(II)-Catalyzed γ-C(sp3)–H Lactamization of Native Amides
0286
Dearomatization? Scandalous! Spiro-Annulation of 2-Arylquinolines with Alkynes by Rare-Earth Catalysis
0287
Palladium-Catalyzed Tritiation of Aryl Thianthrenium Salts
0288
Iron-Catalyzed Regiodivergent Hydrogenation of Epoxides to Alcohols
0289
Copper-Catalyzed Synthesis of Potassium Acyl Trifluoroborates from Carboxylic Acid Derivatives
0290
NHC Ring-Size Matters: Cross-Metathesis of Tetrafluoroethylene and Vinyl Ethers
0291
Nucleophilic C(sp3)–H Functionalization Enabled by Photoredox Catalysis
0292
Enantioselective Intramolecular Oxyamination of Alkenes by Asymmetric Counteranion-Directed Catalysis
0293
Nickel-Catalyzed Bromide-to-Iodide Aromatic Finkelstein Reaction
0294
Bäckvall’s Dynamic Kinetic Resolution

Polymer-Supported Synthesis

z0295
All PDFs of this category
0295
Photocatalytic C–H Arylation of Tertiary Amines with Aryl Nitriles
0296
Photooxidative C–C Bond Cleavage of Lignin Model Compounds under Simulated Solar Radiation
0297
Carbonylative Suzuki–Miyaura and Sonogashira Coupling Reactions with CO2 as a C1 Source
0298
Decarbonylation of Aldehydes Catalyzed by Ceria-Supported Nickel Nanoparticles
0299
Hydrations of Alkynes Catalyzed by a Polyisocyanide-Immobilized Cobalt(III) Porphyrin
0300
Hydrogenation of Nitrobenzenes Using Silver Nanoparticles on Mesoporous Silica Spheres
0301
Copper-Catalyzed Selective Transfer Semihydrogenation of Alkynes
0302
Fluoroalkylation/Distal Functionalization of Nonactivated Alkenes on K-Doped Carbon Nitride
0303
Asymmetric 1,4-Addition with Silica–Polystyrene Hybrid Core/Shell Microparticles of Chiral Rhodium Catalysts
0304
Copper Nanoparticle-Catalyzed Coupling of Arylsulfonyl Hydrazides and Arylboronic Acids
0305
Selective Hydrogenation of Nitroarenes and α,β-Unsaturated Aldehydes over Platinum@Y-Zeolite

Organo- and Biocatalysis

z0307
All PDFs of this category
0307
Engineered Biocatalyst Permits Enantioselective Morita–Baylis–Hillman Reaction
0308
Engineered Metalloenzymes Permit Stereodivergent Radical Cyclization of Alkyl Bromides
0309
Lactam-Recognition Catalysis Permits Highly Selective Deracemizations of Hydantoins
0310
Biocatalytic Platform for Intermolecular Propargylic C–H Amination
0311
Intermolecular Enzyme-Catalyzed endo- and exo-Selective Diels–Alder Reaction
0312
Lithium–Isothiourea–Boronate-Catalyzed Asymmetric Boronate Rearrangements
0313
TfOH/Hexafluoroisopropanol-Promoted Friedel–Crafts Reaction of Arenes with Aliphatic Epoxides or Alcohols
0314
Asymmetric Addition of Enol Silanes to In Situ Generated N-Acyliminium Ions
0315
Asymmetric Catalytic Intermolecular Prins Reaction
0316
Strong Organic Acids Serve as Catalysts in Reversible Addition−Fragmentation Chain-Transfer Polymerization

Chemistry in Medicine and Biology

z0317
All PDFs of this category
0317
Process Development for the Synthesis of Hepatitis C NS5A Protein Inhibitor Odalasvir
0318
Convergent Synthesis of the Antibiotic Amycolamicin
0319
Total Synthesis of Sphingofungins A–D within 10 Steps
0320
A Photoredox-Enabled Arene Radiofluorination for PET Imaging
0321
Synthesis of Tricyclic Prostaglandin D2 Metabolite (PGDM) Streamlined by Transition Metal Catalysis
0322
Disruption of LIN28–let-7 Protein–RNA Interaction by Tricyclic Tetrahydroquinolines as an Anticancer Strategy
0323
Regioselective Alkene Diarylation under Catalyst Control
0324
Optimization of a Noncovalent KRASG12D Inhibitor
0325
Structural Mimicry Against Antibiotic Resistance
0326
A Ring-Expansion Strategy Enables the Discovery of Spiro cRAF Inhibitor SHR902275
0327
Synthesis and Antibiotic Activity of Micrococcin P2
0328
Central Nervous System-Penetrant Inhibitors of ELOVL1
0329
CyLBams Enable Analysis of Antibody–Drug Conjugate Linker Chemistry

Peptide Chemistry

z0331
All PDFs of this category
0331
Thionyl Fluoride-Mediated Peptide Synthesis
0332
Peptide Bond Formation with Ynamide Coupling Reagents
0333
Synthesis of Unnatural α-Amino Acids Mediated by Visible Light
0334
Palladium-Catalyzed Thiazole-Directed C(sp3)–H Arylation of Peptides
0335
Iridium-Catalyzed C–H Amination of Benzoic Acids
0336
Synthesis of β3-Amino Acid Derivatives by Using an Imidodiphosphorimidate Catalyst
0337
Palladium-Catalyzed Decarbonylation of Amino Acid Derivatives with an Aminoquinoline Directing Group
0338
Silver-Catalyzed Enantioselective Synthesis of Pyroglutamic Acid Esters
0339
A Silyl Carbamate Linker for Solid-State Peptide Synthesis in the Reverse Direction

Flow Chemistry

z0341
All PDFs of this category
0341
Sequential Diazo Transfer and Rhodium-Catalyzed O–H Insertion Enabled by the Use of an Azide Resin
0342
Tropylium-Catalyzed Ritter Reaction under Flow Conditions
0343
C–H Sulfonylation of Imidazoheterocycles through Electrochemical Activation in Flow
0344
C–H Phosphorylation of Arenes under Flow Conditions