Synfacts

Issue 04 · April 2022

Recommend Journal

Issue
Synform
A54
Zanda, Matteo: SYNFORM ISSUE 2022/04 FREE ACCESS

Full Text

PDF (2447 kb)
Synthesis of Natural Products and Potential Drugs
z0345
All PDFs of this category

Full Text

PDF (382 kb)
0345
Syntheses of (–)-Crinipellins C and F FREE ACCESS

Full Text

HTML

PDF (133 kb)
0346
Synthesis of MRTX1719

Full Text

HTML

PDF (83 kb)
0347
Total Synthesis of (–)-Lamellodysidine A

Full Text

HTML

PDF (83 kb)
0348
Synthesis of the C1–C13 Fragment of Eribulin

Full Text

HTML

PDF (106 kb)
0349
Total Synthesis of (+)-Madangamine E

Full Text

HTML

PDF (89 kb)
0350
Total Synthesis of (+)-Shizukaol J

Full Text

HTML

PDF (89 kb)
0351
Total Synthesis of (–)-Scabrolide A

Full Text

HTML

PDF (91 kb)
0352
Synthesis of (–)-Triptonide

Full Text

HTML

PDF (85 kb)
0353
Synthesis of CDK7 Inhibitor SY-5609

Full Text

HTML

PDF (85 kb)
0354
Total Synthesis of (+)-Dynemicin A FREE ACCESS

Full Text

HTML

PDF (130 kb)
Synthesis of Heterocycles
z0355
All PDFs of this category

Full Text

PDF (369 kb)
0355
Metal-Free Reduction of Aromatic Nitro Compounds FREE ACCESS

Full Text

HTML

PDF (130 kb)
0356
Synthesis of Trifluoromethylated Azaheterocycles by Radical Chemistry

Full Text

HTML

PDF (79 kb)
0357
Synthesis of 1,2,4-Triazepines by a Base-Induced Formal [4+3] Cycloaddition

Full Text

HTML

PDF (81 kb)
0358
Access to Dibenzo[c,e]azonines by Iron-Catalyzed Alkyne–Carbonyl Metathesis

Full Text

HTML

PDF (79 kb)
0359
Convergent Synthesis of Isoindolines from Cyclic Imines and Organolithium Intermediates

Full Text

HTML

PDF (85 kb)
0360
A Solution to Nickel-Catalyzed Cross-Electrophile-Coupling Woes

Full Text

HTML

PDF (86 kb)
0361
Facile Halogenation of Aminoheterocycles for Rapid Diversification

Full Text

HTML

PDF (86 kb)
0362
Multicomponent Synthesis of Fluorescent Indolizine Tetracycles

Full Text

HTML

PDF (88 kb)
0363
Large-Scale Synthesis of 3-Fluoro-6-methoxyquinoline

Full Text

HTML

PDF (83 kb)
0364
Transition-Metal-Free One-Pot Synthesis of 3-Acylisoxazoles

Full Text

HTML

PDF (96 kb)
0365
TfOH-Promoted Selective C2–N1 Ring-Expansion Reaction of Indazoles

Full Text

HTML

PDF (78 kb)
0366
Organophosphorus-Catalyzed Cyclization of N-(2-Hydroxyethyl)amides

Full Text

HTML

PDF (90 kb)
0367
Visible-Light-Induced Transition-Metal-Free C(sp²)–H Difluoromethylation of Hetarenes

Full Text

HTML

PDF (84 kb)
Synthesis of Materials and Unnatural Products
z0369
All PDFs of this category

Full Text

PDF (279 kb)
0369
From 3-Arylindole to Polycyclic Heteroarenes: Copper-Catalyzed Aerobic Oxidative Annulation

Full Text

HTML

PDF (69 kb)
0370
Zigzag Carbon Nanotube Segments from Gold Rings

Full Text

HTML

PDF (80 kb)
0371
Troponoid Porphyrinoids

Full Text

HTML

PDF (79 kb)
0372
N-Type B–N-Embedded Perylene Diimides

Full Text

HTML

PDF (75 kb)
0373
Do the Twist

Full Text

HTML

PDF (77 kb)
0374
Building BN-Embedded Heteroarenes via Boron Tribromide-Induced Scholl Reaction

Full Text

HTML

PDF (74 kb)
0375
Polymer Diversification: N–O Problem for This Reagent!

Full Text

HTML

PDF (68 kb)
0376
Synthesis of a New Helicene

Full Text

HTML

PDF (89 kb)
0377
PAH with a Boron Heart

Full Text

HTML

PDF (73 kb)
0378
Aromatic Norcorrole Phosphorous Complexes

Full Text

HTML

PDF (84 kb)
0379
Crazy (Nitrogen)-Rich Acenes

Full Text

HTML

PDF (77 kb)
0380
Powerful Barriers for Helicates

Full Text

HTML

PDF (76 kb)
Metals in Synthesis
z0381
All PDFs of this category

Full Text

PDF (1143 kb)
0381
Atroposelective Direct C–H Arylation of Indoles

Full Text

HTML

PDF (80 kb)
0382
Enantioenriched N,O-Ketals via Copper-Catalyzed Asymmetric Addition of Alcohols to Ketimines

Full Text

HTML

PDF (97 kb)
0383
Cyclopropanation of Alkenes via a Siloxycarbene–Palladium Complex FREE ACCESS

Full Text

HTML

PDF (145 kb)
0384
Lights on or Lights off? Controlling Cobalt-Catalyzed Selective Reduction of Ketones or Acids with Light

Full Text

HTML

PDF (80 kb)
0385
The Direct Coupling of Phenols and Amines under Rhodium Catalysis FREE ACCESS

Full Text

HTML

PDF (126 kb)
0386
Rhodium-Catalyzed Desymmetric Intermolecular Arylation of Cyclohexadienones

Full Text

HTML

PDF (94 kb)
0387
Palladium-Catalyzed Formal [3+2], [4+2], and [5+2] Heteroannulation of Non-conjugated Alkenyl Amides

Full Text

HTML

PDF (201 kb)
0388
Iridium-Catalyzed Enantioselective Hydroamination of Terminal Alkenes

Full Text

HTML

PDF (75 kb)
0389
Open It the Right Way: Ru- and Rh-Catalyzed Access to (Cross-)Conjugated Dienoates from Vinylcyclopropanes

Full Text

HTML

PDF (74 kb)
0390
Palladium-Catalyzed Annulation of Diene-Tethered Alcohols with Aminals

Full Text

HTML

PDF (80 kb)
0391
Deuterium Labelling of (Hetero)Arenes Enabled by a Nanostructured Iron Catalyst

Full Text

HTML

PDF (76 kb)
0392
Unzincable! A Lewis Acid-Mediated Suzuki–Miyaura Cross-Coupling Under Base Free Conditions

Full Text

HTML

PDF (81 kb)
0393
Enantioselective Palladium-Catalyzed Hayashi–Miyaura Reaction with Coumarins

Full Text

HTML

PDF (72 kb)
0394
A Nickel-Catalyzed Desymmetrization Approach toward 2,3-Dihydro-1H-inden-1-ols

Full Text

HTML

PDF (86 kb)
0395
Enantioselective Decarbonylative Aryl Addition Across Bicyclic Alkenes

Full Text

HTML

PDF (82 kb)
0396
Nickel-Catalyzed 1,2-Carboaminocarbonylation of Strained Alkenes

Full Text

HTML

PDF (96 kb)
0397
Facile Access to Thiocarboxylic Acid Derivatives via Nickel-Catalyzed Cross-Coupling

Full Text

HTML

PDF (93 kb)
0398
Preparation of Enantioenriched α-Difluoromethylsilanes Enabled by Nickel Catalysis

Full Text

HTML

PDF (94 kb)
0399
Asymmetric Addition of Aryl Iodides to Aldehydes Catalyzed by a Nickel–CyanoBOX Complex

Full Text

HTML

PDF (70 kb)
0400
Pyrimidyl Ethers Replace Pivalates in Asymmetric Enolate Arylation

Full Text

HTML

PDF (89 kb)
0401
Desymmetrization of exo-Cyclic Alkenes via Enantioselective Cobalt-Catalyzed Isomerization

Full Text

HTML

PDF (92 kb)
0402
Deuteration of Benzylic C–H Bonds Enabled by η⁶-Coordination to Rhodium(III)

Full Text

HTML

PDF (94 kb)
0403
A General Approach for Introducing the Trifluoromethylamino Group into Organic Molecules

Full Text

HTML

PDF (78 kb)
0404
Copper-Catalyzed Enantioselective Reductive Aldol Reaction

Full Text

HTML

PDF (97 kb)
0405
Epimerization of Diols under Transient Thermodynamic Control

Full Text

HTML

PDF (82 kb)
0406
The Fukuyama Reduction of Thio Esters to Aldehydes FREE ACCESS

Full Text

HTML

PDF (117 kb)
Polymer-Supported Synthesis
z0407
All PDFs of this category

Full Text

PDF (335 kb)
0407
Polymer-Supported Helical Peptide Catalyst for Enantioselective Nitro-Michael Addition FREE ACCESS

Full Text

HTML

PDF (132 kb)
0408
Carboxylative Cyclization of Propargylic Amines with CO₂ Catalyzed by Silver Nanoparticles

Full Text

HTML

PDF (78 kb)
0409
Suzuki–Miyaura Cross-Coupling on Polystyrene-Supported Palladium Oxide Nanoparticles in Water

Full Text

HTML

PDF (86 kb)
0410
One-Pot Synthesis of Quinazoline-2,4-diones Catalyzed by ZnO Immobilized on Dendric Fibrous Nanosilica

Full Text

HTML

PDF (78 kb)
0411
Palladium-Catalyzed Cyanide-Free Cyanation of Aryl Iodides with Nitromethane

Full Text

HTML

PDF (82 kb)
0412
Selective Transformation of Anilines to Azoxybenzenes, Azobenzenes, or Nitrosobenzenes Catalyzed by Zr(OH)₄

Full Text

HTML

PDF (85 kb)
0413
Graphene Oxide-Catalyzed Trifluoromethylation of Alkynes with Quinoxalinones

Full Text

HTML

PDF (91 kb)
0414
Deuteration and Homocoupling of C(sp)–H Bonds Catalyzed by Cationic Bimetallic Cages

Full Text

HTML

PDF (94 kb)
0415
Alder-Ene Reaction of Allenynamides on Cellulose-Immobilized Copper Nanoparticles

Full Text

HTML

PDF (72 kb)
0416
N-Alkylation of Amines and Ammonia with Alcohols Catalyzed by Cobalt Nanoparticles

Full Text

HTML

PDF (80 kb)
0417
Transfer Hydrogenolysis and Hydrogenation of DNA-Conjugated Substrates in Aqueous Micellar Media

Full Text

HTML

PDF (130 kb)
0418
Direct Esterification of Carboxylic Acids with Alcohols and Thiols on an Amphiphilic Monolith-SO₃H Resin

Full Text

HTML

PDF (69 kb)
Organo- and Biocatalysis
z0419
All PDFs of this category

Full Text

PDF (303 kb)
0419
Direct Cyclopropanations of Olefins with Methylene Compounds via Organoelectrocatalysis FREE ACCESS

Full Text

HTML

PDF (143 kb)
0420
Organophotoredox-Catalyzed Carboxylation of C(sp³)–O Bonds

Full Text

HTML

PDF (93 kb)
0421
Organophotocatalytic Benzylation of Nonactivated Allylic C–H Bonds

Full Text

HTML

PDF (83 kb)
0422
Imidazoline–Phosphoric Acid-Catalyzed Asymmetric Pictet–Spengler Reaction of α-Keto Esters

Full Text

HTML

PDF (97 kb)
0423
Dual Hydrogen-Atom Transfer and Photoredox Catalysis Permits Alkyl Radical Addition

Full Text

HTML

PDF (78 kb)
0424
Enantioselective β-gem-Difluoroalkylation of Enals under Organocatalytic Photoredox Conditions

Full Text

HTML

PDF (113 kb)
0425
Iminophosphorane Catalyst Permits Enantioselective Sulfa-Michael Addition to α,β-Unsaturated Amides

Full Text

HTML

PDF (100 kb)
0426
Organophotocatalytic [2+1] Cycloaddition Toward the Synthesis of Cyclopropenols

Full Text

HTML

PDF (91 kb)
Chemistry in Medicine and Biology
z0427
All PDFs of this category

Full Text

PDF (1475 kb)
0427
Electrochemical Late-Stage Methylation

Full Text

HTML

PDF (81 kb)
0428
Double the Bet: Discovery of Dimeric Cinchona Alkaloid-Inspired Macrocycles as LC3 Lipidation Inducers

Full Text

HTML

PDF (93 kb)
0429
A Novel Thiazolidine Scaffold that Inhibits O-GlcNAcase (OGA) FREE ACCESS

Full Text

HTML

PDF (239 kb)
0430
A Sweet Bonus to Drug Release

Full Text

HTML

PDF (91 kb)
0431
Structural Diversification of 14-Membered Macrolides

Full Text

HTML

PDF (94 kb)
0432
Nitrogen Lovers – Azaphilone Natural Products Inspire the Development of Bioconjugation Reagents

Full Text

HTML

PDF (91 kb)
0433
Iridium, Palladium, Cobalt and Rhodium Came to Hamigeran M’s Party

Full Text

HTML

PDF (85 kb)
0434
Scalable Synthesis of a Key Fluoro-BPin Fragment towards MCL‑1 Inhibitors

Full Text

HTML

PDF (76 kb)
0435
Transition Metal Catalysis Enables an Efficient Synthesis of Soraphen A

Full Text

HTML

PDF (85 kb)
0436
SEAKing Cancer Cells to Locally Activate Prodrugs

Full Text

HTML

PDF (187 kb)
0437
Late-Stage Photocatalytic C–H Olefination

Full Text

HTML

PDF (84 kb)
0438
Photoaffinity Probe Identifies New Cellular Targets of Lenalidomide

Full Text

HTML

PDF (79 kb)
0439
A Cyclic Twist: Enantioselective Formation of Spirocyclic Oxindoles via Double Alkylation

Full Text

HTML

PDF (84 kb)
0440
Novel Photocleavable Protecting Group for Native Chemical Ligation

Full Text

HTML

PDF (83 kb)
0441
Synthesis of Toxicodenane A – A Sesquiterpenoid that Protects Cells from Lipotoxicity

Full Text

HTML

PDF (91 kb)
Peptide Chemistry
z0443
All PDFs of this category

Full Text

PDF (380 kb)
0443
Photocatalytic Synthesis of Amino Acid Amides

Full Text

HTML

PDF (77 kb)
0444
Cinchona Alkaloid-Catalyzed α-Selenylation of Amino Acid Derivatives

Full Text

HTML

PDF (93 kb)
0445
5-Nitro-4,6-dithiocyanatopyrimidine: A Novel Coupling Reagent for Peptide Synthesis FREE ACCESS

Full Text

HTML

PDF (130 kb)
0446
Palladium-Catalyzed Site-Selective Modification

Full Text

HTML

PDF (70 kb)
0447
Synthesis of Peptide Thioesters via Ynamides

Full Text

HTML

PDF (70 kb)
0448
Nickel-Catalyzed C(sp³)–C(sp³) Cross-Coupling for the Synthesis of Unnatural Amino Acids

Full Text

HTML

PDF (67 kb)
0449
Copper-Catalyzed Asymmetric Conjugated Addition to Form Chiral α-Amino Acids

Full Text

HTML

PDF (98 kb)
0450
Ru- or Rh-Catalyzed C–H Functionalization of Amino Acid-Derived Phosphinamides with Alkynes

Full Text

HTML

PDF (81 kb)
0451
Peptide Modification by Bicyclobutane–Triazolinedione Cycloadditions

Full Text

HTML

PDF (75 kb)
0452
Cobalt-Catalyzed Oxidative Functionalization of Cyclic Ethers to Form Fluorinated Amino Acids

Full Text

HTML

PDF (78 kb)
0453
Copper-Catalyzed β-Alkylation of Amino Acid Schiff Bases

Full Text

HTML

PDF (91 kb)
0454
Solid-Phase Synthesis of α-Amino Alkyl or Aryl Phosphonopeptide Derivatives FREE ACCESS

Full Text

HTML

PDF (142 kb)
Flow Chemistry
z0455
All PDFs of this category

Full Text

PDF (120 kb)
0455
Multistep Closed-Loop Optimization for the Synthesis of Edavarone

Full Text

HTML

PDF (85 kb)
0456
Synthesis of (S)-Rolipram via Continuous Flow

Full Text

HTML

PDF (99 kb)
Most Read
Archive
Articles by Category
Free Sample Issue

Journal

More About This Journal
Synfacts Videos
Editorial Board
Editorial Office
Brochure

Authors

Instructions for Authors

Subscription

Subscription Information & Contacts
Institutional Licensing

Nobel Prize 2016

Instructions for Authors

Journals
Book Series
Login
Help
Portal
Return to Classic Website

German English

Thieme E-Books & E-Journals is a service of Georg Thieme Verlag and Thieme Medical Publishers, Inc.
© Georg Thieme Verlag KG

Imprint | Privacy policy statement

Your Current IP Address: 3.14.12.254