DOI: 10.1055/s-00000131

Synfacts

Issue 04 · Volume 18 · April 2022 DOI: 10.1055/s-012-53132

Synform

A54
Zanda, Matteo: SYNFORM ISSUE 2022/04

Synthesis of Natural Products and Potential Drugs

z0345
All PDFs of this category
0345
Syntheses of (–)-Crinipellins C and F
0346
Synthesis of MRTX1719
0347
Total Synthesis of (–)-Lamellodysidine A
0348
Synthesis of the C1–C13 Fragment of Eribulin
0349
Total Synthesis of (+)-Madangamine E
0350
Total Synthesis of (+)-Shizukaol J
0351
Total Synthesis of (–)-Scabrolide A
0352
Synthesis of (–)-Triptonide
0353
Synthesis of CDK7 Inhibitor SY-5609
0354
Total Synthesis of (+)-Dynemicin A

Synthesis of Heterocycles

z0355
All PDFs of this category
0355
Metal-Free Reduction of Aromatic Nitro Compounds
0356
Synthesis of Trifluoromethylated Azaheterocycles by Radical Chemistry
0357
Synthesis of 1,2,4-Triazepines by a Base-Induced Formal [4+3] Cycloaddition
0358
Access to Dibenzo[c,e]azonines by Iron-Catalyzed Alkyne–Carbonyl Metathesis
0359
Convergent Synthesis of Isoindolines from Cyclic Imines and Organolithium Intermediates
0360
A Solution to Nickel-Catalyzed Cross-Electrophile-Coupling Woes
0361
Facile Halogenation of Aminoheterocycles for Rapid Diversification
0362
Multicomponent Synthesis of Fluorescent Indolizine Tetracycles
0363
Large-Scale Synthesis of 3-Fluoro-6-methoxyquinoline
0364
Transition-Metal-Free One-Pot Synthesis of 3-Acylisoxazoles
0365
TfOH-Promoted Selective C2–N1 Ring-Expansion Reaction of Indazoles
0366
Organophosphorus-Catalyzed Cyclization of N-(2-Hydroxyethyl)amides
0367
Visible-Light-Induced Transition-Metal-Free C(sp2)–H Difluoromethylation of Hetarenes

Synthesis of Materials and Unnatural Products

z0369
All PDFs of this category
0369
From 3-Arylindole to Polycyclic Heteroarenes: Copper-Catalyzed Aerobic Oxidative Annulation
0370
Zigzag Carbon Nanotube Segments from Gold Rings
0371
Troponoid Porphyrinoids
0372
N-Type B–N-Embedded Perylene Diimides
0373
Do the Twist
0374
Building BN-Embedded Heteroarenes via Boron Tribromide-Induced Scholl Reaction
0375
Polymer Diversification: N–O Problem for This Reagent!
0376
Synthesis of a New Helicene
0377
PAH with a Boron Heart
0378
Aromatic Norcorrole Phosphorous Complexes
0379
Crazy (Nitrogen)-Rich Acenes
0380
Powerful Barriers for Helicates

Metals in Synthesis

z0381
All PDFs of this category
0381
Atroposelective Direct C–H Arylation of Indoles
0382
Enantioenriched N,O-Ketals via Copper-Catalyzed Asymmetric Addition of Alcohols to Ketimines
0383
Cyclopropanation of Alkenes via a Siloxycarbene–Palladium Complex
0384
Lights on or Lights off? Controlling Cobalt-Catalyzed Selective Reduction of Ketones or Acids with Light
0385
The Direct Coupling of Phenols and Amines under Rhodium Catalysis
0386
Rhodium-Catalyzed Desymmetric Intermolecular Arylation of Cyclohexadienones
0387
Palladium-Catalyzed Formal [3+2], [4+2], and [5+2] Heteroannulation of Non-conjugated Alkenyl Amides
0388
Iridium-Catalyzed Enantioselective Hydroamination of Terminal Alkenes
0389
Open It the Right Way: Ru- and Rh-Catalyzed Access to (Cross-)Conjugated Dienoates from Vinylcyclopropanes
0390
Palladium-Catalyzed Annulation of Diene-Tethered Alcohols with Aminals
0391
Deuterium Labelling of (Hetero)Arenes Enabled by a Nanostructured Iron Catalyst
0392
Unzincable! A Lewis Acid-Mediated Suzuki–Miyaura Cross-Coupling Under Base Free Conditions
0393
Enantioselective Palladium-Catalyzed Hayashi–Miyaura Reaction with Coumarins
0394
A Nickel-Catalyzed Desymmetrization Approach toward 2,3-Dihydro-1H-inden-1-ols
0395
Enantioselective Decarbonylative Aryl Addition Across Bicyclic Alkenes
0396
Nickel-Catalyzed 1,2-Carboaminocarbonylation of Strained Alkenes
0397
Facile Access to Thiocarboxylic Acid Derivatives via Nickel-Catalyzed Cross-Coupling
0398
Preparation of Enantioenriched α-Difluoromethylsilanes Enabled by Nickel Catalysis
0399
Asymmetric Addition of Aryl Iodides to Aldehydes Catalyzed by a Nickel–CyanoBOX Complex
0400
Pyrimidyl Ethers Replace Pivalates in Asymmetric Enolate Arylation
0401
Desymmetrization of exo-Cyclic Alkenes via Enantioselective Cobalt-Catalyzed Isomerization
0402
Deuteration of Benzylic C–H Bonds Enabled by η6-Coordination to Rhodium(III)
0403
A General Approach for Introducing the Trifluoromethylamino Group into Organic Molecules
0404
Copper-Catalyzed Enantioselective Reductive Aldol Reaction
0405
Epimerization of Diols under Transient Thermodynamic Control
0406
The Fukuyama Reduction of Thio Esters to Aldehydes

Polymer-Supported Synthesis

z0407
All PDFs of this category
0407
Polymer-Supported Helical Peptide Catalyst for Enantioselective Nitro-Michael Addition
0408
Carboxylative Cyclization of Propargylic Amines with CO2 Catalyzed by Silver Nanoparticles
0409
Suzuki–Miyaura Cross-Coupling on Polystyrene-Supported Palladium Oxide Nanoparticles in Water
0410
One-Pot Synthesis of Quinazoline-2,4-diones Catalyzed by ZnO Immobilized on Dendric Fibrous Nanosilica
0411
Palladium-Catalyzed Cyanide-Free Cyanation of Aryl Iodides with Nitromethane
0412
Selective Transformation of Anilines to Azoxybenzenes, Azobenzenes, or Nitrosobenzenes Catalyzed by Zr(OH)4
0413
Graphene Oxide-Catalyzed Trifluoromethylation of Alkynes with Quinoxalinones
0414
Deuteration and Homocoupling of C(sp)–H Bonds Catalyzed by Cationic Bimetallic Cages
0415
Alder-Ene Reaction of Allenynamides on Cellulose-Immobilized Copper Nanoparticles
0416
N-Alkylation of Amines and Ammonia with Alcohols Catalyzed by Cobalt Nanoparticles
0417
Transfer Hydrogenolysis and Hydrogenation of DNA-Conjugated Substrates in Aqueous Micellar Media
0418
Direct Esterification of Carboxylic Acids with Alcohols and Thiols on an Amphiphilic Monolith-SO3H Resin

Organo- and Biocatalysis

z0419
All PDFs of this category
0419
Direct Cyclopropanations of Olefins with Methylene Compounds via Organoelectrocatalysis
0420
Organophotoredox-Catalyzed Carboxylation of C(sp3)–O Bonds
0421
Organophotocatalytic Benzylation of Nonactivated Allylic C–H Bonds
0422
Imidazoline–Phosphoric Acid-Catalyzed Asymmetric Pictet–Spengler Reaction of α-Keto Esters
0423
Dual Hydrogen-Atom Transfer and Photoredox Catalysis Permits Alkyl Radical Addition
0424
Enantioselective β-gem-Difluoroalkylation of Enals under Organocatalytic Photoredox Conditions
0425
Iminophosphorane Catalyst Permits Enantioselective Sulfa-Michael Addition to α,β-Unsaturated Amides
0426
Organophotocatalytic [2+1] Cycloaddition Toward the Synthesis of Cyclopropenols

Chemistry in Medicine and Biology

z0427
All PDFs of this category
0427
Electrochemical Late-Stage Methylation
0428
Double the Bet: Discovery of Dimeric Cinchona Alkaloid-Inspired Macrocycles as LC3 Lipidation Inducers
0429
A Novel Thiazolidine Scaffold that Inhibits O-GlcNAcase (OGA)
0430
A Sweet Bonus to Drug Release
0431
Structural Diversification of 14-Membered Macrolides
0432
Nitrogen Lovers – Azaphilone Natural Products Inspire the Development of Bioconjugation Reagents
0433
Iridium, Palladium, Cobalt and Rhodium Came to Hamigeran M’s Party
0434
Scalable Synthesis of a Key Fluoro-BPin Fragment towards MCL‑1 Inhibitors
0435
Transition Metal Catalysis Enables an Efficient Synthesis of Soraphen A
0436
SEAKing Cancer Cells to Locally Activate Prodrugs
0437
Late-Stage Photocatalytic C–H Olefination
0438
Photoaffinity Probe Identifies New Cellular Targets of Lenalidomide
0439
A Cyclic Twist: Enantioselective Formation of Spirocyclic Oxindoles via Double Alkylation
0440
Novel Photocleavable Protecting Group for Native Chemical Ligation
0441
Synthesis of Toxicodenane A – A Sesquiterpenoid that Protects Cells from Lipotoxicity

Peptide Chemistry

z0443
All PDFs of this category
0443
Photocatalytic Synthesis of Amino Acid Amides
0444
Cinchona Alkaloid-Catalyzed α-Selenylation of Amino Acid Derivatives
0445
5-Nitro-4,6-dithiocyanatopyrimidine: A Novel Coupling Reagent for Peptide Synthesis
0446
Palladium-Catalyzed Site-Selective Modification
0447
Synthesis of Peptide Thioesters via Ynamides
0448
Nickel-Catalyzed C(sp3)–C(sp3) Cross-Coupling for the Synthesis of Unnatural Amino Acids
0449
Copper-Catalyzed Asymmetric Conjugated Addition to Form Chiral α-Amino Acids
0450
Ru- or Rh-Catalyzed C–H Functionalization of Amino Acid-Derived Phosphinamides with Alkynes
0451
Peptide Modification by Bicyclobutane–Triazolinedione Cycloadditions
0452
Cobalt-Catalyzed Oxidative Functionalization of Cyclic Ethers to Form Fluorinated Amino Acids
0453
Copper-Catalyzed β-Alkylation of Amino Acid Schiff Bases
0454
Solid-Phase Synthesis of α-Amino Alkyl or Aryl Phosphonopeptide Derivatives

Flow Chemistry

z0455
All PDFs of this category
0455
Multistep Closed-Loop Optimization for the Synthesis of Edavarone
0456
Synthesis of (S)-Rolipram via Continuous Flow