DOI: 10.1055/s-00000131

Synfacts

Issue 05 · Volume 18 · May 2022 DOI: 10.1055/s-012-53357

Synform

A68
Zanda, Matteo: SYNFORM ISSUE 2022/05

Synthesis of Natural Products and Potential Drugs

z0457
All PDFs of this category
0457
Synthesis of a Human Immunodeficiency Virus Maturation Inhibitor
0458
Synthesis of GSK973
0459
Synthesis of Four Kopsane Alkaloids
0460
Synthesis of (–)-Jimenezin
0461
Synthesis of Molibresib
0462
Total Synthesis of Erectones A and B
0463
Total Synthesis of (+)-Hyperforin and (+)-Pyrohyperforin
0464
Synthesis of (+)-Euphorikanin A
0465
Synthesis of BMS-813160
0466
Synthesis of Orexin Receptor Antagonist YZJ-1139
0467
Total Synthesis of (–)-Exiguolide
0468
Synthesis of an Adaptor-Associated Kinase 1 Inhibitor
0469
Synthesis of (±)-Emtricitibine
0470
One-Pot Synthesis of Molnupiravir from Cytidine
0471
Synthesis of Foscarbidopa
0472
Synthesis of GDC-0134
0473
Total Synthesis of (±)-Reserpine

Synthesis of Heterocycles

z0475
All PDFs of this category
0475
New Silaazacycles: Syntheses of 1,3,5-Diazasilinan-2-ones and 1,3,5-Thiazasilinan-2-imines
0476
Synthesis of Fluoroalkylated Benzimidazole- or Indole-Fused Benzoxazines
0477
One-Pot Transition-Metal-Free Synthesis of Thiadiazine 1-Oxides
0478
Modular Access to Functionalized Pyrroles
0479
Copper Photocatalyzed Synthesis of Heterocycles
0480
Synthesis of Bioactive Fluoropyrrolidines through 1,3-Dipolar Cycloadditions of Azomethine Ylides
0481
Stereoselective Synthesis of Sulfinate Esters via a Chiral Ion Pair
0482
Synthesis of 1,2,4-Thiadiazoles in Ethanol at Room Temperature by Using Hydrogen Peroxide
0483
Synthesis of Novel Isoxazoloazaborines from 4-N-Propargylaminoisoxazoles
0484
Enhanced Potency and Properties by Exploiting Substituted Oxetane as a Cyclobutane Bioisostere
0485
Synthesis of Triazolopyridines with Nitrous Oxide
0486
Electrochemical Syntheses of Substituted Morpholine Derivatives
0487
Heteroaromatic C–H Etherification by Using (Benzo)thiophene-Based Halogen-Transfer Reagents
0488
Access to Densely Substituted Furans by a Tsuji–Wacker-Type Cyclization
0489
Expanding Substrate Scope of the Chemoenzymatic Functionalization of Tetrahydroisoquinolines

Synthesis of Materials and Unnatural Products

z0491
All PDFs of this category
0491
Surpassing Sumanene with Ring Expansion
0492
Buckybowl Waterwheels
0493
Transcending Benzoborirene Instability
0494
Building Silacyclohexanones from Divinylsilanes and Allylamines via Rh-Catalyzed Cyclization
0495
Chemoselective Synthesis of Sulfenylated Spiroindolenines from Indolyl-ynones
0496
Upcycling Polyethylene with Mi(tsunobu)das Touch
0497
Closing the Ring with Hydrazine to Make PHAs
0498
Jumbo Calixarene Ligands
0499
Synthesis of Armchair- and Chiral-Type Belts
0500
Queueing Up Cumulenes with Copper Catalysis
0501
Fold-in Approach for Curved Heteronanographene
0502
Through-Space Conjugation to (Violo)generate Longer-Lived Charge Separation

Metals in Synthesis

z0503
All PDFs of this category
0503
An Alternative to Norbornene: Unstrained Alkene Ligands with a Coordination Site for Catellani Reactions
0504
Iridium-Catalyzed Hydroiodination and Formal Hydroamination with N-Iodo Reagents and Hydrogen
0505
General Strategy for the Synthesis of Rare Sugars via Ru(II)-Catalyzed and Boron-Mediated Selective Epimerization of 1,2-trans-Diols to 1,2-cis-Diols
0506
Enantioselective Reductive Coupling of Dienes with Oxetanones and N-Acyl-Azetidinones
0507
Iron Made It: Asymmetric Oxidative Cross-Coupling of 2-Naphthols with 2-Aminonaphthalenes
0508
Asymmetric Allenylation of β-Keto Esters via Cooperative Palladium/Brønsted Acid Catalysis
0509
Iridium-Catalyzed Reductive Alkylation of Amides for the Synthesis of α-Difluoroalkylated Amines
0510
Preparation of α,β-Unsaturated Ketones by Nickel-Catalyzed Reductive Hydroacylation of Alkynes
0511
Palladium-Catalyzed Hydrohalogenation of Terminal and Internal Alkenes under Chain-Walking
0512
Asymmetric Hydrogenation/Cyclization Cascade of Aliphatic Ketoacids: Access to Chiral Lactones
0513
Copper-Catalyzed Cross-Coupling of Alkyl Iodides and Organoboronates via Halogen-Atom Transfer
0514
Acetate-Assisted Thioetherification of Aryl Chlorides under Nickel Catalysis
0515
Nickel/Photoredox Dual-Catalytic Reductive Cross-Coupling of α-Bromo Phosphonates
0516
Rhodium-Catalyzed Enantioselective Ring Expansion of Azetidines
0517
Enantioselective Cross-Coupling of Alkenyl Boronates and Carbamoyl Chlorides
0518
Access to Chiral Tertiary Alkyl Halides by Catalytic Reductive Desymmetrization of Malonic Esters
0519
Synthesis of Skipped Dienes and Vinylcyclopropanes by Pd-Catalyzed Cross-Coupling of Alkenyl Hydrazones
0520
Directed Allene C(sp2)−H Activation Catalyzed by Palladium
0521
Cooperative Stereoinduction in Asymmetric Photocatalysis
0522
Enantioselective Copper-Catalyzed Cyanobenzoyldifluoromethylation of Olefins
0523
Where to Go? Selective 1,2- or 1,4-Diarylation of 1,3-Dienes under Ni/Cr Cocatalysis
0524
Zinc About It: Highly Regio- and Stereoselective Iron-Catalyzed Alkylzincation of Terminal Alkynes
0525
Nickel-Catalyzed Cross-Coupling of Aryl Bromides with Aryl Sulfonium Salts
0526
Peptide Bond Formation via Silacyclic Compounds
0527
The Enantioselective Overman Rearrangement
0528
Amino-Acid Promoted Ullmann-Type C–N Coupling

Polymer-Supported Synthesis

z0529
All PDFs of this category
0529
Catalytic Hydration/Enantioselective Reductive Amination Cascade Reaction of Propargyl Ethers
0530
Copper-Catalyzed Synthesis of Aminobenzotriazoles from o-Phenylenediamines
0531
Photocatalytic Enantioselective α-Benzylation of Aldehydes on a Covalent Organic Framework
0532
An Iron-Modified Molybdenum-Based Polyoxometalate Catalyst for Direct Amide Synthesis
0533
Photochemical Hydroxylation of β,γ-Unsaturated Oximes on Carbon Nitride
0534
Novel Palladium–Zirconia Nanocomposites for the Carbonylative Suzuki–Miyaura Coupling
0535
Cycloaddition of Carbon Dioxide to Epoxides on N,S Co-Doped Carbon
0536
A Zinc(II) Catalyst for the Synthesis of Cyclic Carbonates and Cyclic Carbamates from Carbon Dioxide
0537
Photocatalyzed Oxidative Coupling of Tetrahydroisoquinolines with Carbon Nucleophiles
0538
Alcohol Ammoxidation Catalyzed by Palladium Nanoparticles under Visible-Light Irradiation
0539
Arylation of C(sp3)–H Bonds with a Cerium-Based Metal–Organic Framework Catalyst

Organo- and Biocatalysis

z0541
All PDFs of this category
0541
Directed Evolution Toward Nonstandard Amino Acids by a Decarboxylative Aldol Reaction
0542
Synthesis of Cyclobutanes through Enantioselective Intermolecular [2+2] Photocycloadditions
0543
Engineered Metalloenzymes Permit Enantiodivergent N–H Insertion of Carbenes into Primary Amines
0544
Design and Application of a Novel Chiral Brønsted C−H Superacid
0545
Photo- and Organocatalytic Enantioselective Giese-Type Addition to Alkenyl Azaarenes
0546
Bifunctional Pyridoxal-Catalyzed Asymmetric α-Allylation of Glycinates with Switched Chemoselectivity
0547
Reagent-Dependent Photoredox-Catalyzed Radical 5-exo and 6-endo Cyclization of Allyloxypyridines
0548
Pyridinium Umpolung through N-Heterocyclic Carbene Catalysis
0549
Prolylurea-Catalyzed Pictet–Spengler Reaction of Tryptamine and Keto Amides
0550
Organophotocatalytic Site-Selective Heteroarylation of Indoles
0551
A Biocatalytic Cascade Approach to Chiral N-Substi-tuted 1,2-Amino Alcohols from Simple Building Blocks
0552
Biocatalytic Production of N-Hydroxycytidine

Chemistry in Medicine and Biology

z0553
All PDFs of this category
0553
A Wakeup Call for Exhausted CAR T Cells – Targeted Delivery of an Immune Stimulant
0554
An Alternative Reactivity of Sulfonyl Fluorides
0555
A Testimony of Hergenrother’s Rule
0556
Asymmetric Synthesis of Bioactive Lignans and Enantiomeric Antiviral Activity of Niranthin
0557
Total Synthesis of Two Fusicoccanes Identified Potent Anticancer Activities of a Synthetic Intermediate
0558
A Photoswitchable Butyrylcholinesterase Inhibitor for Investigating Alzheimer’s Disease
0559
Fluorogenic Labeling of Nucleic Acids in Living Cells
0560
Potent and Selective PI3Kδ Inhibitors for the Treatment of Hepatocellular Carcinoma
0561
Synthesis of a Redshifted Photolabile Protecting Group Based on a NIR Dye via a DFT-Based Design
0562
Discovery of Non-Nucleotide STING Agonists
0563
The First Total Synthesis of (±)-Forskolin

Peptide Chemistry

z0565
All PDFs of this category
0565
Cyclopeptide Synthesis by Ring-Closing Metathesis
0566
Iridium-Catalyzed Synthesis of α-Amino Esters by α-Amidation
0567
Synthesis of Fluorine-Containing Amino Acids from Sulfamidates and Potassium Fluoride
0568
Diastereoselective Allylation of α-Imino Esters for the Synthesis of Sterically Hindered Amino Ester and Peptides
0569
Copper-Catalyzed Silylamination for the Synthesis of β-Silyl-α-amino Acids
0570
Enantioselective Synthesis of Unnatural Amino Acids Catalyzed by a Chiral Phosphoric Acid
0571
Double Mannich Alkylamination to Form Benzofuran-Fused Amino Acid Derivatives
0572
Trimethoxy(methyl)silane-Mediated Amidation of Carboxylic Acids
0573
Design and Synthesis of a Thiazolium-Based Coupling Reagent for Peptide Synthesis

Flow Chemistry

z0575
All PDFs of this category
0575
Alkyl Phosphonate Synthesis in a Continuous-Flow System
0576
Oxidative Photocyclization of N-Arylenaminones to Indoles in Flow
0577
Continuous Flow, Cyanide-Free Cyanation Procedure via a Suzuki Coupling, [4+2] retro-[4+2] Sequence
0578
Efficient Synthesis of AZD4635 using Oxygen in Flow