DOI: 10.1055/s-00000131

Synfacts

Issue 02 · Volume 19 · February 2023 DOI: 10.1055/s-013-56347

Synform

A18
Zanda, Matteo: SYNFORM ISSUE 2023/02

Synthesis of Natural Products

z0111
All PDFs of this category
0111
Syntheses of Preussomerins
0112
Total Synthesis of (−)-Sinulochmodin C
0113
Total Synthesis of (–)-Peyssonnoside A
0114
Synthesis of (+)-Periglaucine C
0115
Total Synthesis of (+)-Havellockate
0116
Total Synthesis of the Grayanoid (–)-Principinol C
0117
Total Synthesis of (+)-Monensin

Synthesis of Heterocycles

z0119
All PDFs of this category
0119
Multigram Synthesis of pivZPhos Ligand
0120
Asymmetric Reductive Transamination for the Synthesis of Chiral Piperidines
0121
Room Temperature Metal-Free Heteroaryl Hydrogenation
0122
Ru(II)-Catalyzed Synthesis of Bridged Tetracycles via C–H Allylation and [3+2] Dipolar Cycloaddition
0123
Synthesis and Application in Ni-Mediated C–C Cross-Couplings of a Modular Series of Novel Ligands
0124
Scalable Synthesis of Enantiopure Bicyclic Fluorinated Pyrrolidinol
0125
Enantioselective Transannular Reaction of Macrocyclic Sulfonamides
0126
Two-Step Regioselective Trifluoropropylation of Azoles
0127
Pyrimidines to Pyrazoles Under Mild Conditions
0128
Merging Known Pharmacophores: Synthesis of Substituted N-Indolizines
0129
Building 3-Borylated Pyrrolidines via 1,3-Dipolar Cycloaddition
0130
Efficient Ni-Mediated Cyanation of (Hetero)Aryl Halides under Homogeneous Conditions
0131
Three-Step, One-Pot Regioselective C-3 Trifluoromethylation of Quinolines
0132
Elemental Sulfur-Mediated Annulation of Enaminones to Access 2-Aminofurans and 2-Aminthiophenes

Synthesis of Materials and Unnatural Products

z0133
All PDFs of this category
0133
A Giant Photonic Ring
0134
Halogen-Atom Transfer Enabled Indole Synthesis
0135
[4]Acenes from Double Cyclizations of Fluoroalkene
0136
Tetraaryl Dihydropentalenes
0137
Pyridinium-Promoted Hydroarylation of Aryl Alkynes
0138
A Squarephaneic Tetraanhydride for Porous Materials
0139
Corralarenes: Conjugated Tubular Macrocycles
0140
Lossen Rearrangement to Thiocarbamates
0141
A Single-Step Atroposelective Construction
0142
B/N-Doped Acenaphthylene and Acenaphthene
0143
Azaborole Helicenes with Double Helical Axes
0144
Easy Access to Azatriphenylenes

Metals in Synthesis

z0145
All PDFs of this category
0145
Atroposelective Ring-Closing Metathesis of Stereo-dynamic Trienes to Access Chiral Binaphthalenes
0146
Enantioselective Benzylic C–H Cyanation by Merging Electrophoto- and Copper Catalysis
0147
Synthesis of Diastereo- and Enantioenriched Homoallylic Alcohols with a Chiral CF3- and F-Bound Carbon
0148
Syntheses of Diarylmethanes via Silver or Synergic Silver/Scandium-Catalyzed Benzannulation Reactions
0149
Dual Photoredox/Copper Catalysis Enables Asymmetric Cyanation via 1,4-Heteroaryl Migration
0150
Carbon and Silyl Electrophiles Hand in Hand: Nickel-Catalyzed Regioselective Carbosilylation of Acrylonitrile
0151
Enantioconvergent Carboxylation of Racemic Benzylic (Pseudo)Halides under Nickel Catalysis
0152
Enantioselective Pd(0)-Catalyzed Carbonitration Reaction via Alkyl–Pd(II)–ONO2Reductive Elimination
0153
Amination of Aryl Halides Enabled by Dual Nickel/Red-Light-Metallaphotoredox Catalysis
0154
Three-Component Cross-Electrophile Silylarylation of 1,3-Dienes under Nickel Catalysis
0155
Hydroalkenylation of Strained 3- and 4-Membered Carbocycles under Photoinduced Palladium Catalysis
0156
Pd-Catalyzed Synthesis of Tetrasubstituted Phthalans from Haloarenes, Alkynes, and Protic Nucleophiles
0157
Palladium Domino Cyclization/β-Carbon Elimination Reaction Generating Axially Chiral Compounds
0158
Cross-Coupling of Alkyl Fluorides with Lipshutz Cuprates under Aluminum Iodide-Mediated C–F Bond Activation
0159
Ruthenium-Catalyzed Isomerization of 3°-Allylic Alcohols via a β-Aryl Elimination
0160
Enantioselective 1,6-Addition of Chiral Boryl–Alkyl Nucleophiles to para-Quinone Methides
0161
Synthesis of 1,1-Diarylalkanes via a Photoinduced Cobalt-Catalyzed Hydroarylation of Styrenes
0162
Rhodium-Catalyzed Asymmetric Hydrosilylation of β,β-Disubstituted Enamides to α-Aminosilanes
0163
Hydrodecarboxylation of Carboxylic Acids under Cooperative Iron–Thiol Catalysis
0164
Copper-Catalyzed Synthesis of N-Cyanomethyl Amide via a Claisen Rearrangement
0165
Synthesis of Borylated Allenes via Iron-Catalyzed Functionalization of Propargylic Acetates
0166
Access to α-Chiral Tertiary Amines by Cobalt-Catalyzed Enantioselective Hydroamination of Arylalkenes
0167
Stereoselective Rhodium-Catalyzed Enyne–Cyclobutanone Annulation
0168
Ru(II)-Catalyzed Three-Component Reaction Toward the Synthesis of Chromeno[4,3-c]pyrazol-4-ones
0169
Kinetic Resolution/Enantioselective Alkynylation of Alkyl Allylic Alcohols under Iridium Catalysis
0170
Enantioselective Photocatalyzed Radical Addition to Ketones

Polymer-Supported Synthesis

z0171
All PDFs of this category
0171
Metal-Free Oxidative C–C Bond Cleavage of Ketones Promoted by Biomass-Derived Carbons
0172
α-Alkylation of Acetamides with Alcohols Catalyzed by Ruthenium Nanoparticles
0173
Photocatalytic C−S Coupling Using Colloidal Carbon Dots and NiBr2∙dtbbpy
0174
Decarbonylation of 1,2-Diketones Catalyzed by Au–Pd Nanoparticles Supported on CeO2
0175
Phosphorylation of Tetrahydroisoquinolines and Oxidation of Sulfides by 4CzIPN-Based Porous Polymers
0176
Chemoselective Hydrogenation of Nitroarenes by Cobalt Single-Atom Catalysts
0177
Suzuki Coupling and Heck Reaction Using Pd NPs Supported on Catechol−Functionalized MWCNTs
0178
Ring-Opening Hydrosilylation or Dehydrogenative Silylation of Cyclopropyl Aldehydes and Ketones
0179
A3-Coupling Catalyzed by Gold Nanoparticles Supported on γ-AlO(OH)
0180
Hydrogenation of Aromatic Rings and Cleavage of Etheric C–O Bonds by a Ruthenium Single-Atomic Catalyst
0181
Photocatalytic Oxidation of Benzylamines and Thioanisoles by a Buta-1,3-diene-Linked COF

Organo- and Biocatalysis

z0183
All PDFs of this category
0183
N-Heterocyclic Carbene (NHC) Catalysis Permits Diastereoselective Radical Aminoacylation of Olefins
0184
Chiral Phosphoric Acid-Catalyzed Diels–Alder Reaction of 2-Trifluoroacetamido-1,3-Dienes and Enones
0185
Hypervalent Iodine Catalyst Grants Access to 1,4-Difunctionalized Fluorinated Olefins
0186
Conformational Fixation of Organocatalyst in Metal-Organic Framework Permits Improved Enantiocontrol

Innovative Drug Discovery and Development

z0187
All PDFs of this category
0187
“Click-to-Release” Biorthogonal Chemophototherapy
0188
Ervogastat: A Potent and Selective Inhibitor of DGAT2 for the Treatment of NASH
0189
Multivariate Linear Regression Informs Ligand Design to Improve the Synthesis of a KRAS Inhibitor
0190
A Comprehensive Study of Myxobacterial Corramycin
0191
Total Synthesis of Pentosinane
0192
Fluorinated Peptoid-Capped Histone Deacetylase Inhibitors
0193
Metabolically Stable HDAC Inhibitors with Improved Selectivity Utilizing a Novel Zinc-Binding Group
0194
Glycoconjugation of Andrographolide Improves Neuroprotective Potential
0195
Design and Synthesis of a Potent, Orally Active Direct Renin Inhibitor for Hypertension
0196
High-Affinity Brain-Penetrant Ph-HTBA for CaMKIIα Modulation
0197
Taming Heterogeneous Reactions to Access PROTAC Linkers Using Flow Chemistry
0198
Highly Efficient Construction of Polyols Through Boronic Ester Homologation – Synthesis of Bahamaolide A
0199
A Green High-Yielding 7-Step Synthesis of Nirmatrelvir

Peptide Chemistry

z0201
All PDFs of this category
0201
Late-Stage Functionalization for the Construction ­of Proline Skeleton in Peptides
0202
N-Indole-Protected Peptide Synthesis
0203
Pd-Catalyzed Deuteration of Amino Acids
0204
Cu-Catalyzed Hydrogermylation of Dehydro Amino Acids
0205
Three-Component Coupling to Afford α,α-Diaryl Amino Acids
0206
α-Amino Acid Amidation Using a Silicon Reagent
0207
Indolylation of N-2-Nitrophenylsulfenyl Imino Peptides
0208
C–H Functionalization at the β-Position of Dehydroamino Acids
0209
Chemoselective Cleavage of the tert-Butoxycarbonyl Group from Di-tert-butylimidodicarbonate

Flow Chemistry

z0211
All PDFs of this category
0211
Synthesis of Fentanyl Using Photoredox Catalysis under Flow