DOI: 10.1055/s-00000131

Synfacts

Ausgabe 04 · Volume 21 · April 2025 DOI: 10.1055/s-015-61305

Synthesis of Natural Products

z331
All PDFs of this category
331
Synthesis of (+)-Moluccensin G and (+)-Krishnolide F
332
Total Synthesis of (–)-Veratramine
333
Synthesis of (–)-Azorellolide
334
Total Synthesis of (+)-Isochamaecydin
335
Total Synthesis of (–)-Strempeliopine
336
Total Synthesis of (–)-Isolinearol
337
Synthesis of (±)-Roseophilin

Synthesis of Heterocycles

z339
All PDFs of this category
339
Skeletal Editing to Access Substituted Aminoisoquinolines
340
Construction of Pyridoquinazolinones from Benzoic Acids and 2-Aminopyridines Using Copper Catalysis
341
A One-Step Approach for the Synthesis of C–C-Linked Glutarimides
342
Easy Access to 2‑Methylquinazolin-4(3H)‑ones from 2-Aminobenzamides and Calcium Carbide
343
An IMDA/Aromatization Sequence for Isoindolinone Synthesis
344
Azlactone Incorporation Facilitating Versatile Ring Expansion of Unstrained N-Heterocycles
345
Pyrrole Derivatization through a Haloform Reaction
346
Synthesis of 2-Quinolones via Intramolecular Electrophilic Amination by Nitrenium Ions
347
Development of Library Protocols Based on Core Syntheses of Heterocycles
348
A Transition-Metal-Free Approach to Access Pyrazolopyridines and Pyrazolopyrimidines
349
Nitrene-Mediated Ring Expansion of Five-Membered N-Heterocycles
350
Modular Synthesis and Reactivity of Hetero[3.1.1]propellanes
351
Logistical Ligand Design Enables Enantioselective Remote C–H Activation

Synthesis of Materials and Unnatural Products

z353
All PDFs of this category
353
Supramolecular Snub Cubes with Chirality
354
An M9L6 Supermolecular Cage
355
Cyclic [4]Catenanes
356
Zigzag Aromatic Nanotubes of Truncated Cone Shape
357
A Triplet Dianthraceno[2,3-a:3′,2′-h]-s-indacene
358
Conjugated Ladder Polymers of Cyclooctatetraene
359
Unsymmetrical Pyrenes via a Quadruple Photochemical Cascade
360
Centrosymmetric Double Difluoroboron Cores: New Narrowband Emitters
361
Diboron-Enabled [5,5]-Sigmatropic Rearrangement
362
Octacyclic Scaffolds from Diaryl Alkynes in One Pot
363
Arenesulfenyl Fluorides for Fluorosulfenylation
364
π-Extended Arsabenzenes

Metals in Synthesis

z365
All PDFs of this category
365
Photoredox-Catalyzed Acylesterification of Alkenes Using Acyloxime Esters as Bifunctional Reagents
366
Copper-Catalyzed Enantioselective Hydrocupration of Cyclic Allenol Esters
367
β-Trifluoromethylalkylation of Silyl Enol Ethers under Dual Nickel and Photoredox Catalysis
368
Palladium-Catalyzed β-C–H Activation and Arylation of Ketones and Esters
369
Asymmetric Addition of N-Heterobiaryl Triflates to Aldehydes under Dual Cobalt and Photoredox Catalysis
370
Regioselective Product Formation Induced by Selection of the Base Cation
371
Copper-Photocatalyzed Defluorinative C(sp3)–O Coupling of Trifluoromethylarenes and Alcohols
372
Sequential C–H Activations for the Synthesis of P‑Stereogenic Benzophosphole Oxides
373
Magnesium-Promoted Ring Expansion of Donor–Acceptor Cyclopropanes to Azetidines
374
Synthesis of Silacycles via Double Hydroalumination and Intramolecular Cyclization
375
C4-Alkylation and Arylation of Pyridine via Metalation with Butylsodium
376
Photocatalytic Decarboxylative Fluoroalkylation of α,β-Unsaturated Carboxylic Acids
377
A Hydrogen-Borrowing Strategy for the Construction of Carbocycles Containing Quaternary Stereocenters
378
Asymmetric Synthesis of Allylic Amines by Reductive Coupling of Internal Alkynes and Imines
379
Metallaphotoredox-Catalyzed Single-Carbon-Atom Insertion into Alkenes for Allene Synthesis
380
Silver-Catalyzed Z-Selective Hydroalkylation of Terminal Conjugated Alkynes Using Alkyl Boranes
381
Thermodynamic Isomerization of cis-1,2- to trans-1,2-Cyclopropanols
382
Copper-Catalyzed Asymmetric Alkylboration of 3,3-Disubstituted Cyclopropenes
383
Nickel-Catalyzed Arylation of 1,1-Disubstituted Alkenes To Access Stereodefined Quaternary Carbons
384
Photocatalytic Dehydrogenation of Cycloalkanes to Arenes
385
Silver-Mediated Peptide Coupling of Thioamides via O–N Acyl Transfer
386
Enantioselective C(sp3)–H Arylation of Acetonides by Dual Nickel and Decatungstate Photocatalysis
387
Ruthenium-Catalyzed Hydration of N-Heterocycles Enables Access to Lactams
388
Photoredox-Catalyzed Bromocyanodifluoromethylation of Unsaturated Hydrocarbons
389
An Asymmetric Karasch–Sosnovsky Oxygenation of Allylic and Propargylic C–H Bonds
390
Gold(I)-Catalyzed Propargyl Claisen Rearrangement

Polymer-Supported Synthesis

z391
All PDFs of this category
391
Triarylamine-Mediated Electrochemical [2+2+2] Cycloaddition Forming 3,6-Diarylpyridines
392
Synthesis of N-Sulfonyl Amidines in Water Using a Magnetic CoFe2O4-Supported CuI Catalyst
393
Synthesis of γ-Sultines through Photo-induced Sulfonylation–Sulfinylation of Terminal Arylalkenes
394
Decarbonylative Silylation of Cinnamaldehydes Using a Zr-Based MOF-Supported Ru Photocatalyst
395
Phenolic Resin Photocatalysts for Aerobic Oxidation of Sulfides and Benzylamines
396
The Synthesis of Quinazolines and Quinazolinones Promoted by a Single-Cobalt-Atom Catalyst under Air
397
Amination of Phenols Using Single-Site Palladium on CeO2
398
Oxidative Dehydrogenation of Tetrahydroquinolines Using a Three-Dimensional Mesoporous COF
399
CuPd Bimetallic Nano Catalysts for the C–H Arylation of Azoles
400
Synthesis of Cyclic Carbonates from Epoxides and CO2 Using Polystyrene-Supported Ionic Liquid Catalysts
401
Ni- or Ru-Zeolite-Catalyzed Continuous-Flow Dehydrative Synthesis of Macrocyclic Ethers and Lactones

Organo- and Biocatalysis

z403
All PDFs of this category
403
Photoredox- and Metalloenzyme-Catalysis Enables Enantioselective Radical Azidations and Thiocyanations
404
Bifunctional Dihydrazide Catalysis Involves Nucleophilic Enamine Activation
405
Asymmetric N-Alkylation of o-Carboranyl Amines Using Chiral Phosphoric Acids
406
Silylium-Based Asymmetric Counteranion-Directed Catalysis Involving Peroxycarbenium Intermediate
407
Organocatalytic Asymmetric Transfer Hydrogenation of 2-Substituted Quinolines
408
Taming Highly Enolizable Aldehydes via Enzyme Catalysis
409
Stereoselective Trifluoromethylation of Olefins and Nitro Compounds Catalyzed by Old Yellow Enzymes
410
Organocatalytic Decarboxylation of Indoline-3-carboxylic Acids
411
Synthesis of Complex Piperidines via a Biocatalytic C–H Oxidation/Radical Cross-Coupling Sequence
412
Organophotocatalytic Alkene and Indole Carboxyalkylation via CO2•–

Innovative Drug Discovery and Development

z413
All PDFs of this category
413
Practical Approach toward gem-Difluorinated Ring Expansion of Exocyclic Alkenes
414
Aminoalkylation of Alkenes via Triple Radical Sorting
415
Leveraging Metabolic Reprogramming 2-Quinolones to Treat MRSA-Infected Wounds
416
Decarboxylation: Innovation and Functionalization
417
Iron-Enabled Anti-Markovnikov Photocatalytic Hydro- and Deuterochlorination
418
Practical Approach for Diverse Functionalization of Complex Small Molecules via Thianthrenium Salts
419
Development of a Tepotinib-Based PROTAC as a Potential Lung Cancer Therapeutic
420
Convenient Access to Heteroaromatic Methyl Sulfones
421
Chemoselective and Mild Conditions for Controlled Reductions of Carboxylic Acid Esters
422
Diazirines in a New Light: Chromophore Conjugation Indicates a Functional sp2-Hybridized Carbon Center
423
Scaffold Hopping with IL-17 Antagonists – Exploiting an Oxygen-to-Sulfur Interaction to Favor Planarity
424
Getting to the Root of Pulmonary Arterial Hypertension: Designing Novel Pyridine-2-one AMPK Inhibitors
425
Diastereoselective Synthesis of Benzazepines via Pd(II)-Catalyzed [3+2] Cycloaddition
426
One Starting Material, Two Directions: Acyl and Decarbonylative Couplings of Anhydrides

Peptide Chemistry

z427
All PDFs of this category
427
Cobalt-Catalyzed Synthesis of Silicon-Containing Amino Acids and Peptides
428
Peptide Bond Formation of Unprotected Amino Acids in H2O–THF
429
S–S-Linked Peptide Synthesis via Disulfuration of Azlactone
430
Gram-Scale Synthesis of Spirocyclic Prolines and Pyroglutamic Acids
431
Photoredox-Catalyzed Synthesis of Unnatural Amino Acid Derivatives
432
Synthesis of Chiral Amino Esters by Asymmetric Branched-Selective Ring-Opening Functionalization
433
Synthesis of α-Amino Esters via Catalytic Enantioselective Nucleophilic Amination
434
Backbone Amidoxime Ether Directed C(sp3)–H Functionalization of Peptides by Palladium Catalysis
435
Synthesis of Metallo-Azapeptides by Composed Chelation of Peptide Backbone Nitrogen with a Metal
436
Accessing Unblocked Racemic Tryptophan Derivatives by Using a Nickel(II) Complex of Gramine
437
Palladium-Catalyzed Aminocarbonylation of Peptides for the Synthesis of N-Capped Peptides
438
Photoinduced Regiodivergent and Enantioselective Alkylation of Glycine Derivatives
439
Copper-Catalyzed Difluoroalkylation for Glycine Derivatives
440
Chemoselective Deprotection of Fmoc and OMe in N-Fmoc-Amino Acid and N-Fmoc-Dipeptide Methyl Esters

Flow Chemistry

z441
All PDFs of this category
441
Highly Efficient and Reusable Resin Catalyzes the Ritter Reaction in Flow