Direct Accessing γ-Pyridyl Tertiary Alcohols through Metal-Free Three-Component Reactions

Abstract

Herein, we introduce a novel method for synthesizing γ-pyridyl alcohols from readily accessible alcohols. This process is a metal-free, three-component reaction that elegantly combines alcohols, vinylarenes, and 4-cyanopyridine. The versatility of this reaction is showcased through its successful application in the late-stage functionalization of pharmaceutical molecules.

Key words

alcohols hydrogen atom transfer - metal-free - multicomponent reaction - benzophenone

Publication History

Received: 25 October 2024

Accepted after revision: 11 December 2024

Accepted Manuscript online:
11 December 2024

Article published online:
31 January 2025

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