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Synfacts 2008(12): 1299-1299  
DOI: 10.1055/s-0028-1087321
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

New C 1-Symmetric Diene Ligands in Rhodium-Catalyzed 1,2-Addition

Contributor(s): Mark Lautens, Jane Panteleev
T. Gendrineau, O. Chuzel, H. Eijsberg, J.-P. Genêt, S. Darses*
Ecole Nationale Supérieure de Chimie de Paris, France
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

Diene ligands are increasingly used in metal-catalyzed processes since the pioneering studies of Hayashi, Carreira and co-workers (J. Am. Chem. Soc. 2003, 125, 11508; J. Am. Chem. Soc. 2004, 126, 1628). The authors report the use of a new diene ligand in the 1,4-addition of boronic acids to enones. The C 1-symmetric ligands are for the first time applied in this rhodium addition chemistry producing enantioselectivity on par with the previously examined C 2-symmetric dienes.