Synthesis of Ciguatoxin

A. Hamajima; M. Isobe

doi:10.1055/s-0029-1217612

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Synfacts 2009(9): 0941-0941
DOI: 10.1055/s-0029-1217612

Synthesis of Natural Products and Potential Drugs

Synthesis of Ciguatoxin

Contributor(s): Philip Kocienski
A. Hamajima, M. Isobe*
Nagoya University, Japan

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Publication History

Publication Date:
21 August 2009 (online)

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Significance

The acetylene function plays a critical strategic role in this elegant synthesis of ciguatoxin. It mediates two fragment linkage reactions and two annulation sequences involving Co₂(CO)₆ complexes of propargylic acetates.