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Synfacts 2009(9): 0946-0946  
DOI: 10.1055/s-0029-1217619
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Serratezomine A

Contributor(s): Philip Kocienski, Arndt W. Schmidt
A. Chandra, J. A. Pigza, J.-S. Han, D. Mutnick, J. N. Johnston*
Vanderbilt University, Nashville, USA
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Publication History

Publication Date:
21 August 2009 (online)

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Significance

The Lycopodium alkaloid (+)-serratezomine A was isolated from the club moss ­Lycopodium serratum during a search for new therapeutics. The enamine F was used as the lynchpin molecule to generate the quaternary ­center at C12 by multiple additions to that carbon atom.