One-Pot Oxidation-Wittig Reaction with Ruthenium
Catalyst

E. Y. Lee; Y. Kim; J. S. Lee; J. Park

doi:10.1055/s-0029-1217648

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Synfacts 2009(9): 1052-1052
DOI: 10.1055/s-0029-1217648

Polymer-Supported Synthesis

One-Pot Oxidation-Wittig Reaction with Ruthenium Catalyst

Contributor(s): Yasuhiro Uozumi, Toshimasa Suzuka
E. Y. Lee, Y. Kim, J. S. Lee, J. Park*
Pohang University of Science and Technology, Republic of Korea

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Publication History

Publication Date:
21 August 2009 (online)

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Significance

Ruthenium nanoparticles entrapped in highly porous aluminum oxyhydroxide [Ru/AlO(OH)] were applied to the one-pot oxidation-Wittig reaction. Thus, the Ru/AlO(OH) 1 was prepared from ruthenium(III) chloride hydrate, EtOH, and Al(s-OBu)₃ according to the reported procedures (Org. Lett. 2006, 8, 2543). The one-pot oxidation-Wittig reaction of benzyl alcohol with Ph₃P=CHCO₂Me was carried out with Ru/AlO(OH) to give the methyl cinnamate in 94% yield. Catalyst 1 was recovered and reused four times with an eventual gradual decrease in activity.