Synfacts 2009(9): 1008-1008  
DOI: 10.1055/s-0029-1217667
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

H8BINOL-Catalyzed Enantioselective Alkyl Propiolate Addition to Aliphatic Aldehydes

Contributor(s): Hisashi Yamamoto, Zhi Li
M. Turlington, A. M. DeBerardinis, L. Pu*
University of Virginia, Charlottesville, USA
Further Information

Publication History

Publication Date:
21 August 2009 (online)

Significance

Alkyl propiolate addition to aromatic aldehydes is a well-studied field but aliphatic ­aldehydes remain challenging. In this report, H8BINOL and titanium tetraisopropoxide are combined to catalyze the highly enantioselective propiolate addition to aliphatic aldehydes.