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Synfacts 2009(9): 1008-1008
DOI: 10.1055/s-0029-1217667
DOI: 10.1055/s-0029-1217667
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
H8BINOL-Catalyzed Enantioselective Alkyl Propiolate Addition to Aliphatic Aldehydes
M. Turlington, A. M. DeBerardinis, L. Pu*
University of Virginia, Charlottesville, USA
Further Information
Publication History
Publication Date:
21 August 2009 (online)
Significance
Alkyl propiolate addition to aromatic aldehydes is a well-studied field but aliphatic aldehydes remain challenging. In this report, H8BINOL and titanium tetraisopropoxide are combined to catalyze the highly enantioselective propiolate addition to aliphatic aldehydes.