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Synfacts 2009(9): 1028-1028
DOI: 10.1055/s-0029-1217763
DOI: 10.1055/s-0029-1217763
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Gold-Catalyzed Synthesis of Piperidin-4-ones
L. Cui, Y. Peng, L. Zhang*
University of Nevada, Reno, USA
Further Information
Publication History
Publication Date:
21 August 2009 (online)
Significance
An efficient method for the direct synthesis of piperidin-4-ones using gold catalysis has been developed. This gold-catalyzed protocol benefits from its compatibility with basic amines which are known to coordinate and poison rhodium catalysts.