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Synfacts 2010(2): 0143-0143
DOI: 10.1055/s-0029-1219032
DOI: 10.1055/s-0029-1219032
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Inhibitors of Neuropeptide Y
M. Ando et al.*
Tsukuba Research Institute, Merck Research Laboratories, Banyu Pharmaceutical Company, Tsukuba, Japan
Further Information
Publication History
Publication Date:
21 January 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201002/lookinside/thumbnails/10.1055-s-0029-1219032-1.jpg)
Significance
Neuropeptide Y (NPY) is a 36 amino acid neurotransmitter that is widely distributed in both the central and peripheral nervous system. The concentration of NPY is markedly increased in the hypothalamus during food deprivation. NPY Y5 (one of the receptor sub-types) is involved in feeding regulation and energy expenditure and therefore inhibitors of it are of interest as potential anti-obesity agents.