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Synfacts 2010(2): 0220-0220
DOI: 10.1055/s-0029-1219060
DOI: 10.1055/s-0029-1219060
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Fe-Catalyzed Cross-Coupling of Alkenyl Carboxylates with Grignard Reagents
B.-J. Li, L. Xu, Z.-H. Wu, B.-T. Guan, C.-L. Sun, B.-Q. Wang, Z.-J. Shi*
Peking University, Sichuan Normal University, Chengdu and State Key Laboratory of Organometallic Chemistry, Shanghai, P. R. of China
Further Information
Publication History
Publication Date:
21 January 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201002/lookinside/thumbnails/10.1055-s-0029-1219060-1.jpg)
Significance
FeCl2 was found to catalyze the cross-coupling reaction of activated alkenyl pivalates with Grignard reagents. The reaction proceeds under mild conditions and usually gives high yields. Functionalities, such as acetal and olefin are tolerated. Some aryl carboxylates can also be used in this coupling reaction.