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Synfacts 2010(2): 0172-0172
DOI: 10.1055/s-0029-1219083
DOI: 10.1055/s-0029-1219083
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag
Stuttgart ˙ New York
Isolation and Synthesis of Fluorubine Derivatives
J. Fleischhauer, R. Beckert*, Y. Jüttke, D. Hornig, W. Günther, E. Birckner, U.-W. Grummt, H. Görls
Friedrich-Schiller-Universität Jena and Universität Kassel, Germany
Further Information
Publication History
Publication Date:
21 January 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201002/lookinside/thumbnails/10.1055-s-0029-1219083-1.jpg)
Significance
In the process of studying the cascade reactions of Δ²-1,2-diazetines, such as 2, the authors discovered a highly fluorescent orange decomposition product which they determined to be compound 3. Derivatives of 3 exhibit high fluorescent quantum yields (67-100%) and are stable against oxidative damage. Photodecomposition of compound 2 only yielded traces amounts of 3; therefore, the authors desired and developed a more efficient synthesis of this family of compounds starting from 4 in order to study its properties.