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Synfacts 2010(2): 0231-0231
DOI: 10.1055/s-0029-1219138
DOI: 10.1055/s-0029-1219138
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Organocatalytic Asymmetric Relay Cascade with Tunable Stereoselectivity
Y. Wang, R.-G. Han, Y.-L. Zhao, S. Yang, P.-F. Xu*, D. J. Dixon*
Lanzhou University, P. R. of China and University of Oxford, UK
Further Information
Publication History
Publication Date:
21 January 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201002/lookinside/thumbnails/10.1055-s-0029-1219138-1.jpg)
Significance
Xu, Dixon and colleagues report an asymmetric organocatalytic relay cascade reaction, which combines three substrates (1, 2 and 3) and two different catalysts (4 and 5) in the same pot to generate polysubstituted cyclohexanes. As expected for a multistep process in which several steps are asymmetrically catalyzed, excellent enantiomeric excess was obtained for the products while diastereoselectivity was moderate.