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Synfacts 2010(2): 0205-0205
DOI: 10.1055/s-0029-1219211
DOI: 10.1055/s-0029-1219211
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Stereoselective Synthesis of Quinolizidines and Indolizidines
D. Yang, G. C. Micalizio*
The Scripps Research Institute, Jupiter, USA
Further Information
Publication History
Publication Date:
21 January 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201002/lookinside/thumbnails/10.1055-s-0029-1219211-1.jpg)
Significance
Substituted indolizidines and quinolizidines are heterocyclic motifs found in a wide range of bioactive natural products and have been the topic of considerable interest in organic and medicinal chemistry. The authors report a convergent stereoselective synthesis of substituted indolizidines and quinolizidines 4 through chemoselective coupling of functionalized allylsilanes 1 with imines 2. These highly substituted and stereodefined systems were obtained in good yield and high stereoselectivity.